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The Journal of Internal Korean Medicine > Volume 27(1); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(1): 126-137.
定喘化痰湯 등 수종 방제의 호흡기 객담분비 조절 효능에 관한 실험적 연구
김준명1, 이충재2, 박양춘1
1대전대학교 한의과대학 폐계내과학교실
2충남대학교 의과대학 약리학교실
Studies on the Effects of Selected Oriental Herbal Medicines on Inhibitory Activity of Airway Mucus Secretion
Joon-myoung Kim1, Chung-jae Lee2, Yang-chun Park1
1Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University, Daejoen, Korea
2Dept. of Pharmacology, College of Medicine, Chungnam University, Daejeon, Korea
Correspondence  Yang-chun Park ,Tel: 043-229-3704, Fax: 043-253-8757, Email: omdpyc@dju.ac.kr
Received: February 10, 2006,   Accepted: February 27, 2006,   Published online: March 30, 2006.
ABSTRACT
In the present study, the author intended to investigate whether three oriental medical prescriptions named Jeongcheonhwadam- tang(JHT), Haengso-tang(HST), Socheungryong-tang(SCRT) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. The results were as follows : (1) JHT significantly inhibited mucin release from cultured HTSE cells, without significant cytotoxicity : (2) HST significantly inhibited mucin release from cultured HTSE cells, without significant cytotoxicity : (3) SCRT significantly inhibited mucin release from cultured HTSE cells, without significant cytotoxicity : (4) JHT, HST chiefly inhibited the ‘mucin’ release and did not significantly affect the release of the other releasable glycoproteins with less molecular weight than mucin. These results suggest that the three herbal prescriptions specifically inhibit the release of mucin : (5) JHT significantly inhibited the expression levels of MUC 5AC mRNA. This result suggests that JHT affects the synthesis of mucin at gene level in cultured HTSE cells. All agents showed no significant cytotoxicity. In view of these results, further investigation of the effects of JHT and HST are likely to be instrumental in yielding novel agents from oriental medical prescriptions which have inhibitory effects or expectorative effects on airway mucus secretion.
Key words: airway, mucus, Jeongcheonhwadam-tang(JHT), Haengso-tang(HST), Socheongryong-tang(SCRT)
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