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The Journal of Internal Korean Medicine > Volume 27(2); 2006 > Article
The Journal of Internal Korean Medicine 2006;27(2): 336-344.
202種 韓藥材의 IFN-γ 분비조절에 관한 비교연구
이시형1, 강미숙2, 최유경1, 전찬용1, 박종형1, 김동우1
1경원대학교 한의과대학 내과학교실
2경원대학교 한의과대학 침구과교실
Comparative study of 202 herbs on interferon-gamma secretion
See-Hyung Rhee1, Mi-Suk Kang2, You-Kyung Choi1, Chan-Yong Jun1, Chong-Hyeong Park1, Dong-Woo Kim1
1Department of Internal Medicine, Kyungwon University Oriental Medicine Hospital
2Department of Acupuncture & Moxibustion, Kyungwon University Oriental Medicine Hospital
Correspondence  Dong-Woo Kim ,Tel: 02-425-3456, Fax: 02-425-3560, Email: kidow@hanmail.net
Received: April 15, 2006,   Accepted: June 13, 2006,   Published online: June 30, 2006.
ABSTRACT
Objects:
This study has been carried out to assess the effects of the variable herbs on IFN-γ secretion in the mouse spleen cell.

Methods :
202 kinds of herb extracts were used to evaluate the IFN-γ secretory distinction by each 1㎍/㎖ and 10㎍/㎖ density of water. All experimental herbs were grouped by oriental herbalogical method. But each herb had its independent variables.

Results:
The secretions increased in 20% of all herbal water. The density differences also make different effects on the secretion of IFN-γ. The secretion of IFN-γ incresed in some kinds of herbs of IFN-γ. It has representatively increased in Imperatae Rhizoma(白茅根) of 1㎍/㎖ and Notopterygii Rhizoma(羌活) of 10㎍/㎖. IFN-γ incresed in 12 kinds of herbs of both densities. The secretion of IFN-γ decreased in some kinds of herbs of IFN-γ. It has representatively decreased in Moutan Radicis Cortex(蘇丹皮) of 1㎍/㎖ and Angelicae Radix(當歸尾) of 10㎍/㎖. IFN-γ decreased in 18 kinds of herbs of both densities. In the oriental herb group, The secretion of IFN-γ increased in Bang-Hyang-Hwa-Sup group(芳香化濕藥), He-Pyo group(解表藥), I-Su-Sam-Sup group(利水滲.) The secretion of IFN-γ decreased in Gu-Chung group(驅蟲藥), An-Sin group(安神藥), Su-Sap group(收澀, On-Li group(溫裏藥), I-Gi group(理氣藥).

Conclusions:
The result ofthis study will not only broaden applications of oriental medicine to biological therapy, but also form the basis of oriental medical therapy to find out the meaning of oriental classification.
Key words: interferon gamma, IFN-γ, mouse, spleen, Oriental Herb, screening
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