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The Journal of Internal Korean Medicine > Volume 28(4); 2007 > Article
Original Article
The Journal of Internal Korean Medicine 2007;28(4): 830-837.
뇌졸중 위험지표로서의 혈중 지질에 대한 환자 - 대조군 연구
김정현1, 강경원2, 유병찬2, 최선미2, 백혜기1, 임승민1, 안정조1, 설인찬1, 김윤식1
1대전대학교부속한방병원 심계내과학교실
2한국한의학연구원 의료연구부
A Case-Control Study on Blood Lipids as a Risk Factor of Stroke
Jung-hyun Kim1, Kyung-won Kang2, Byeong-chan Yu2, Sun-mi Choi2, Hye-ki Baek1, Seung-min Lim1, Jung-jo An1, In-chan Seol1, Yoon-sik Kim1
1Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University
2Dept. of Medical Research, Korea Institute of Oriental Medicine
Correspondence  Yoon-sik Kim ,Tel: 042-229-6806, Fax: 042-254-3403, Email: yoonsik@dju.ac.kr
  Published online: December 30, 2007.
ABSTRACT
Background and purpose :
Stroke is one of the most deadly diseases and a leading cause of disability. Lipids confer an increased risk for cardiovascular morbidity and mortality. In spite of many studies on the relationship between stroke and lipids, their relationship is not clear. This study was undertaken to determine whether lipids were associated with stroke.

Method:
We compared the components of blood lipids between stroke patients group (n=217,Cases), non-stroke control group (n=160, Controls) and healthy control group without hypertension, diabetes mellitus, ischemic heart disease, or hyperlipidemia (n=140, Normals). These data were statically analyzed by general linear models and binary logistic regression analysis to get each adjusted odds ratio.

Result:
The results were as follows. The blood levels of total cholesterol (T-Chol), triglyceride (TG) and low density lipoprotein cholesterol (LDL-Chol) were significantly higher in patients of ischemic stroke, while the blood levels of T-Chol and LDL-Chol were significantly lower, and the blood levels of TG significantly higher in patients of hemorrhagic stroke. The blood level of high density lipoprotein cholesterol (HDL-Chol) was significantly lower in all cases.

Conclusion:
These results suggest that high TG and low HDL-Chol may be risk factors of hemorrhagic stroke and ischemic stroke, high T-Chol and LDL-Chol may be risk factors of ischemic stroke, and low T-Chol and LDL-Chol may be risk factors of hemorrhagic stroke in Koreans.
Key words: stroke, case-control study, risk factor, lipid, cholesterol
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