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The Journal of Internal Korean Medicine > Volume 28(4); 2007 > Article
Original Article
The Journal of Internal Korean Medicine 2007;28(4): 850-862.
무증상 뇌경색의 위험요인에 대한 환자 - 대조군 연구
백혜기1, 고미미2, 유병찬2, 방옥선2, 오영선3, 김연진3, 김정현1, 김윤식1, 설인찬1
1대전대학교부속한방병원 심계내과학교실
2한국한의학연구원 의료연구부
3대전대학교 혜화병원
The Case-Control Study of Risk Factors of Silent Cerebral Infarction
Hye-ki Baek1, Mi-mi Ko2, Byeong-chan Yu2, Ok-sun Bang2, Yeong-seon Oh3, Yeon-jin Kim3, Jung-hyun Kim1, Yoon-sik Kim1, In-chan Seol1
1Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University
2Dept. of Medical Research, Korea Institute of Oriental Medicine
3Hae-hwa Hospital, Daejeon University
Correspondence  In-chan Seol ,Tel: 042-229-6805, Fax: 042-254-3403, Email: seolinch@dju.ac.kr
  Published online: December 30, 2007.
ABSTRACT
Background:
Cerebrovascular disease is a major cause of death and disability in adults. Silent cerebral infarction (SCI) portends more severe cerebral infarction or may lead to insidious progressive brain damage resulting in vascular dementia. Known cardiovascular risk factors, such as arterial hypertension, diabetes mellitus, smoking, hyperlipidemia and ischemic heart disease may increase the risk of SCI. This study was designed to evaluate the risk factors of SCI in an apparently normal adult population.

Methods :
We divided 340 neurologically normal adults (mean age=59.90±8.30, men:women = 146:194) who underwent brain computed tomography (CT) or magnetic resonance imaging (MRI) at the Stroke Medical Center in Daejeon University Oriental Medicine Hospital in two groups, Silent inf. and Controls,and analyzed risk factors of SCI by interview, physical examination and blood test. Risk factors of SCI were assessed by interview, physical examination and blood test. We performed Pearson's chi-square test and two-sample t-test for univariate analysis and multiple logistic regressions for multivariate analysis to evaluate risk factors of SCI.

Results:
Old age, diabetes mellitus, and high lactate dehydrogenase (LDH) levels were associated with SCI on univariate analysis. Diabetes mellitus was demonstrated to be an independent risk factor for SCI on multivariate analysis.

Conclusions:
Advanced age, diabetes mellitus, and LDH levels are associated with SCI.
Key words: silent cerebral infarction, risk factor, case-control study
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