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The Journal of Internal Korean Medicine > Volume 25(2); 2004 > Article
The Journal of Internal Korean Medicine 2004;25(2): 288-297.
Streptozotocin으로 유발된 당뇨쥐에 대한 白蠶의 혈당 및 당대사 효소활성에 관한 효과
정병무1, 현민경1, 신원용1, 김미랑1, 신현철2, 윤철호1, 정지천1
1동국대학교 한의과 대학 내과학 교실
2대구한의대학교 한의과 대학 내과학 교실
Effects of Bombycis corpus on Streptozotocin-induced Diabetic Rats
Byoung-Mu Jeong1, Min-Kyung Hyun1, Won-Yong Sin1, Mi-Rang Kim1, Hyeon-Cheol Shin2, Cheol-Ho Yoon1, Ji-Cheon Jeong1
1Department of Internal Medicine, College of Oriental Medicine, Dongguk Universty
2Department of Internal Medicine, College of Oriental Medicine, Daegu Haany Universty
Correspondence  Byoung-Mu Jeong ,Tel: 054)770-1341, Fax: 054)770-1500, Email: mania@ur21.org
Received: April 29, 2004,   Accepted: May 18, 2004,   Published online: June 30, 2004.
ABSTRACT
Objective :
This study was undertaken to investigate how Bombycis corpus (BC) effects the development and progress of complications occurring in Diabetes Mellitus (DM).

Methods :
Laboratory rats were seperated into three groups; normal, rats with DM and treated with BC, and rats with DM and not treated. In this study DM was experimentally induced through injection of streptozotocin. The BC treated group was *given BC extract p.o. for 15 days. Then, The activities of glucose phosphatic enzymes and polyol pathway channels· were·observed.

Results:
The blood glucose level greatly increased in the DM groups after injection of streptozotocin, but it significantly decreased in the BC treated group. Significantly enhanced levels of serum insulin levels were seen in the BC treated group, while supressed levels were seen in the untreated DM group. Weight was recovered by the BC treated group, matching the normal group. Decreased enzyme activity of aldose reductase, sorbitol dehydrogenase and glucose-6-phosphatase were seen in BC treated diabetic rats. Increased enzyme activity of the glucokinase and hexokinase were seen in BC treated diabetic rats.

Conclusions:
This study suggests that BC normalized the blood glucose and serum insulin levels destablized by DM. Because increased activity of glucose phosphatic enzymes, glucokinase and hexokinase, and decreased glucose-6-phosphatase activity, and suppression of polyol pathway enzymes, aldose reductase and sorbitol dehydrogenase, were all seen, these observations suggest that BC suppresses blood glucose levels and prevents complications due to DM.
Key words: Diabetes Mellitus, Bombycis corpus, hexokinase, glucokinase, polyol pathway
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