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The Journal of Internal Korean Medicine > Volume 25(2); 2004 > Article
The Journal of Internal Korean Medicine 2004;25(2): 277-287.
珍糖元의 고혈당 조절 작용 및 기전에 관한 연구
김형준, 윤철호, 정지천
동국대학교 한의과대학 내과학교실
Effects of Jindangwon extract in streptozotocin-induced diabetic rats
Hyung-Jun Kim, Cheol-ho Yoon, Ji-Cheon Jeong
Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University
Correspondence  Ji-Cheon Jeong ,Tel: 02)3416-9731, Fax: 02)3444-9171, Email: jjcjh@hitel.net
Received: April 28, 2004,   Accepted: May 18, 2004,   Published online: June 30, 2004.
Objective :
Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications showed that oxidative stress might play a major role. Therefore, many efforts have been made to regulate oxygen free radicals for treating diabetes and its complications. Because Jindangwon has been known to be effective in treatment of diabetes, the methanol extract of Jindangwon was tested for its effectiveness in reducing the oxidative stress induced by Streptozotocin.

Methods :
Jindangwon was washed, dried in the shade and crushed. The crushed Jindangwon was extracted 3 times, each time with 3 volumes of methyl alcohol at 60°C for 24 hours. The extract was filtered and evaporated under reduced pressure using a rotary evaporator to yield 30.6 g. Jindangwon extract was oral-administered to the diabetic rats induced by streptozotocin 50 mg per 1 kg of body weight for 15 days. The efficacy of the Jindangwon extract was examined with regard to the enzymatic pathways involved in the oxygen free radical production and the glutathione balance.

he effects of the methanol extract of Jindangwon in streptozotocin-induced diabetics rats with regard to body weight, blood glucose level, hepatic lipid peroxide level, hepatic xanthine oxidase activity and type conversion rate, hepatic glutathione level, hepatic glutathione peroxidase activity, hepatic glutathione reductase activity, hepatic aldose reductase activity, and hepatic sorbitol dehydrogenase activity were favorable enough to suggest that it is a cure for diabetes and its complications.

These results support Jindangwon as an effective reducing agent for oxidative stress in the tissues and organs by regulating the production of oxygen free radicals. Jindangwon, in particular, shows promising results for its use as a cure, or preventative medicine for diabetes and its complications by reducing oxidative stress in beta-cells of the pancreas.
Key words: Jindangwon, aldose reductase, sorbitol dehydrogenase, diabetes, streptozotocin
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