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The Journal of Internal Korean Medicine 2004;25(2): 238-244. |
| 淸金降火湯 및 瓜蔞枳實湯이 呼吸器 杯狀細胞로부터의 뮤신 分泌에 미치는 영향 |
| 이정은, 박양춘 |
| 대전대학교 한의과대학 폐계내과학교실 |
| Effects of CheongGeumGangHwa-Tang(CGGH), GwaRuJiSil-Tang(GRJS) on mucin secretion from airway goblet cells |
| Joung-eun Lee, Yang-chun Park |
| Department of Internal Medicine, College of Oriental Medicine, Daejeon University, Daejeon, Korea |
| Correspondence |
Yang-chun Park ,Tel: 043)229-3704, Fax: 043)253-8757, Email: omdpyc@dju.ac.kr
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Received: April 14, 2004, Accepted: April 26, 2004, Published online: June 30, 2004. |
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| ABSTRACT |
Objective :
This study is intended to investigate whether the two oriental medical prescriptions, CheongGeumGangHwatang( CGGH) and GwaRuJiSil-tang(GRJS), significantly affect mucin release from cultured hamster tracheal surface epithelial(HTSE) cells.
Materials and Methods :
Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of CGGH or GRJS to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of CGGH and GRJS on contractility of isolated tracheal smooth muscle were investigated.
Results:
(1) CGGH and GRJS significantly increased mucin release from cultured HTSE cells, without cytotoxicity : (2) CGGH and GRJS did not affect contractility of isolated tracheal smooth muscle.
Conclusions:
These results suggest that the effects of CGGH and GRJS should be further investigated, and that it would be gainful to invesigate, from among oriental medical prescriptions, what novel agents have these mild expectorant effects on mucin secretion from airway goblet cells. |
| Key words:
HTSE, airway goblet cell, mucin, cheonggeumganghwa-tang(CGGH), gwarujisil-tang(GRJS) |
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