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The Journal of Internal Korean Medicine > Volume 25(2); 2004 > Article
The Journal of Internal Korean Medicine 2004;25(2): 195-201.
중풍환자 1기 고혈압에 淸血丹의 항고혈압 효과
윤상필, 김이동, 이상호, 김은주, 김태훈, 박영민, 정동원, 신원준, 정우상, 배형섭
경희대학교 한의과대학 2 내과학 교실
Antihypertensive effect of Chunghyul-dan(Qingxue-dan) on stage 1 hypertensive patients with stroke
Sang-pil Yun, Lee-dong Kim, Sang-ho Lee, Eun-ju Kim, Tai-hun Kim, Young-min Park, Dong-won Jung, Won-jun Shin, Woo-sang Jung, Hyung-sup Bae
Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University, Seoul, Korea
Correspondence  Sang-pil Yun ,Tel: 02-958-9129, Fax: 02-958-9132, Email: yunpaul@yahoo.co.kr
Received: April 10, 2004,   Accepted: May 4, 2004,   Published online: June 30, 2004.
Background and Purpose :
Hypertension is one of the modifiable risk factors for stroke. Lowering blood pressure is a primary or secondary preventative measure for stroke. This study aims to assess the efficacy of Chunghyul-dan(Qingxue-dan) in stage 1 hypertensive patients who have suffered a stroke by 24 hour ambulatory blood pressure monitoring(24ABPM).

Subjects & Methods :
We enrolled 40 hospitalized stroke patients with stage 1 hypertension and divided them into 2 groups by stratified randomization; group A took 1200mg of Chunghyul-dan(Qingxue-dan) at 8:00 a.m. for two weeks without changing herbal medicine, and group B was the control group. 28 patients were included in the final analysis(15 in group A, 13 in group B). Blood pressure is monitored from 8:00 am to 7:30 am every 30 minutes for 24 hours. Blood pressure was monitored two times at baseline and again two weeks later. We used 3 parameters for evaluating the efficacy of Chunghyul-dan(Qingxue-dan); The first parameter is change from baseline to two weeks later in blood pressure and pulse rate. The second parameter is the trough/peak ratio(TPR) and smoothness index(SI). The third parameter is antihypertensive rate by antihypertensive efficacy guideline.

There is no significant difference in the baseline assessment between the two groups. Systolic blood pressure (141.37±8.96 mmHg vs 132.28±9.46 mmHg) decreased after two weeks of 1200mg(P=0.03) intake of Chunghyuldan( Qingxue-dan). Systolic TPR and SI was 0.87 and 1.04 in group A. Antihypertensive rate was higher in group A.

These results suggest that 1200mg doses of Chunghyul-dan(Qingxue-dan) is an effective antihypertensive agent on stage 1 hypertension patients who have suffered a stroke.
Key words: Hypertension, Stroke, Chunghyul-dan(Qingxue-dan), TPR, SI
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