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The Journal of Internal Korean Medicine > Volume 25(2); 2004 > Article
The Journal of Internal Korean Medicine 2004;25(2): 195-201.
중풍환자 1기 고혈압에 淸血丹의 항고혈압 효과
윤상필, 김이동, 이상호, 김은주, 김태훈, 박영민, 정동원, 신원준, 정우상, 배형섭
경희대학교 한의과대학 2 내과학 교실
Antihypertensive effect of Chunghyul-dan(Qingxue-dan) on stage 1 hypertensive patients with stroke
Sang-pil Yun, Lee-dong Kim, Sang-ho Lee, Eun-ju Kim, Tai-hun Kim, Young-min Park, Dong-won Jung, Won-jun Shin, Woo-sang Jung, Hyung-sup Bae
Department of Cardiovascular and Neurologic Diseases(Stroke Center) College of Oriental Medicine, Kyung-Hee University, Seoul, Korea
Correspondence  Sang-pil Yun ,Tel: 02-958-9129, Fax: 02-958-9132, Email: yunpaul@yahoo.co.kr
Received: April 10, 2004,   Accepted: May 4, 2004,   Published online: June 30, 2004.
ABSTRACT
Background and Purpose :
Hypertension is one of the modifiable risk factors for stroke. Lowering blood pressure is a primary or secondary preventative measure for stroke. This study aims to assess the efficacy of Chunghyul-dan(Qingxue-dan) in stage 1 hypertensive patients who have suffered a stroke by 24 hour ambulatory blood pressure monitoring(24ABPM).

Subjects & Methods :
We enrolled 40 hospitalized stroke patients with stage 1 hypertension and divided them into 2 groups by stratified randomization; group A took 1200mg of Chunghyul-dan(Qingxue-dan) at 8:00 a.m. for two weeks without changing herbal medicine, and group B was the control group. 28 patients were included in the final analysis(15 in group A, 13 in group B). Blood pressure is monitored from 8:00 am to 7:30 am every 30 minutes for 24 hours. Blood pressure was monitored two times at baseline and again two weeks later. We used 3 parameters for evaluating the efficacy of Chunghyul-dan(Qingxue-dan); The first parameter is change from baseline to two weeks later in blood pressure and pulse rate. The second parameter is the trough/peak ratio(TPR) and smoothness index(SI). The third parameter is antihypertensive rate by antihypertensive efficacy guideline.

Results:
There is no significant difference in the baseline assessment between the two groups. Systolic blood pressure (141.37±8.96 mmHg vs 132.28±9.46 mmHg) decreased after two weeks of 1200mg(P=0.03) intake of Chunghyuldan( Qingxue-dan). Systolic TPR and SI was 0.87 and 1.04 in group A. Antihypertensive rate was higher in group A.

Conclusion:
These results suggest that 1200mg doses of Chunghyul-dan(Qingxue-dan) is an effective antihypertensive agent on stage 1 hypertension patients who have suffered a stroke.
Key words: Hypertension, Stroke, Chunghyul-dan(Qingxue-dan), TPR, SI
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