| 順氣和中湯과 Doxorubicin의 병용이 Colon-26의 항암효과에 미치는 영향 |
| 신민규, 김봉석, 오중한, 임희용, 김동우, 최빈혜, 변준석 |
| 대구한의대학교 한의과대학 비계내과학교실 |
| The Anti-tumor Effect of Soonkiwhajungtang with Doxorubicin in Colon-26 |
| Min Kyu Shin, Bong-Suk Kim, Jung-Han Oh, Hee-Yong Lim, Dong Woo Kim, Bin-Hye Choi, Joon-Seok Byun |
| Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University, Daegu, Korea |
| Correspondence |
Joon-Seok Byun ,Tel: 053-770-2113, Fax: 053-770-2169, Email: jsbyun@dhu.ac.kr
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Received: March 24, 2004, Accepted: April 19, 2004, Published online: June 30, 2004. |
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| ABSTRACT |
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In order to evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against Colon-26(Murine Rectum Carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst 3LL cell lines. Soonkiwhajungtang may only mimic direct anti-tumor effects against 3LL cell lines, but signs of worsening induced by implantation of tumor cell lines generally decreased, while the total WBC and lymphocyte numbers increased. Therefore, experimentation suggests that Soonkiwhajungtang extracts reduced the critical toxicity of doxorubicin, and that Soonkiwhajungtang extracts have favorable synergic effects when combined with doxorubicin. |
| Key words:
Soonkiwhajungtang, doxorubicin, anti-tumor effect, Colon-26 |
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