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The Journal of Internal Korean Medicine > Volume 25(2); 2004 > Article
The Journal of Internal Korean Medicine 2004;25(2): 174-182.
滋陰降火湯의 알레르기성 炎症反應抑制效果
김유경, 김홍준, 김우성, 박형진, 문구, 김동웅, 원진희
원광대학교 한의과대학 비계내과학 교실
Inhibitory Effect of Jaeumganghwa-tang on Allergic Inflammatory Reaction
Yu-Kyung Kim, Hong-Joon Kim, Woo-Sung Kim, Hyoung-Jin Park, Goo Moon, Dong-Woung Kim, Jin-Hee Won
Department of Internal Medicine, College of Oriental Medicine, Wonkwang University
Correspondence  Yu-Kyung Kim ,Tel: 062-670-6527, Fax: 062-670-6529, Email: kyklis76@hanmail.net
Received: March 24, 2004,   Accepted: April 16, 2004,   Published online: June 30, 2004.
This study investigates Jaeumganghwa-tang(JGT) has been used for the purpose of prevention and treatment of allergic inflammatory diseases. This study was to investigate the biological effects of JGT.

Methods :
Cytotoxcicity and inflammatory cytokines secretion with human mast cells(HMC-1) were examined. HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. JGT by itself had no effect on cytotoxicity of HMC-1. The effects of JGT on the secretion of tumor necrosis factor-alpha(TNF-α) and interleukin(IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay(ELISA).

It was found that JGT inhibited PMA plus A23187-induced TNF-αand IL-6 secretion. JGT also inhibited the NF-¥OE B(p50) expression.

These results suggest that JGT inhibits the secretion of inflammatory cytokines in HMC-1 cells through blockade of NF-¥OEB activation. Taken together, these effects support a role for JGT as a therapeutic agent in treatment of allergic inflammatory diseases such as asthma.
Key words: Jaeumganghwa-tang(JGT), human mast cells(HMC-1), TNF-α, NF-¥OEB
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