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The Journal of Internal Korean Medicine > Volume 42(5); 2021 > Article
The Journal of Internal Korean Medicine 2021;42(5): 820-832.
doi: https://doi.org/10.22246/jikm.2021.42.5.820
Crizotinib과 한방치료를 병행하여 호전된 ROS1 양성 재발성 폐암 환자 1례
장권준1,2, 양정민1, 이지윤1, 고은비1, 문향란1, 윤민지1, 조온유1, 정성헌1, 이범준2, 신광순1, 황우석1,2
2경희대학교대학원 임상한의학과 폐계내과학교실
A Case Report on ROS1-positive Recurrent Non-small-cell Lung Cancer Treated with Crizotinib and Korean Medicine
Kwon-jun Jang1,2, Jung-min Yang1, Ji-yoon Lee1, Eun-bi Ko1, Hyang-ran Moon1, Min-ji Yoon1, On-you Jo1, Seong-heon Jeong1, Beom-joon Lee2, Kwang-soon Shin1, Woo-seok Hwang1,2
1Jangdeuk Korean Medicine Hospital
2Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University
Correspondence  Woo-seok Hwang ,Tel: 1800-1135, Fax: 02-593-2052, Email: pato-@nate.com
Received: September 2, 2021,   Accepted: October 19, 2021,   Published online: October 30, 2021.
This study examined the case of a patient with ROS1-positive recurrent non-small-cell lung cancer treated with crizotinib and traditional Korean medicine.

The patient was treated with crizotinib from January 20 2021 to May 22 2021, together with Haedogyangpye-tang and Haengso-tang. The tumor size was measured using computed tomography (CT), and adverse events were evaluated according to the National Cancer Institute’s Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0.

After four months of combined treatment, the sizes of the lymph nodes in the porta hepatis, hepatoduodenal, retrocrural, aortocaval, and para-aortic areas had decreased, and no lymph nodes larger than 1 cm in diameter were observed. The side effects of chemotherapy also improved.

This case study suggests that traditional Korean medicine may alleviate the side effects of chemotherapy, improve quality of life, and complement chemotherapy itself.
Key words: ROS1, non-small cell lung cancer, crizotinib, traditional Korean medicine
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