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The Journal of Internal Korean Medicine > Volume 40(1); 2019 > Article
The Journal of Internal Korean Medicine 2019;40(1): 13-37.
doi: https://doi.org/10.22246/jikm.2019.40.1.13
비알콜성 지방간질환의 한방치료에 대한 체계적 문헌고찰
이유리, 조나경, 최홍식, 김승모, 김경순
대구한의대학교 한의과대학 간계내과학교실
A Systematic Review of Korean Medicine for Non-Alcoholic Fatty Liver Disease
Yu-ri Lee, Na-kyung Cho, Hong-sik Choi, Seung-mo Kim, Kyung-soon Kim
Dept. of Korean Internal Medicine of Hepatology, College of Korean Medicine, Daegu Haany University
Correspondence  Kyung-soon Kim ,Tel: 053-770-2081, Fax: 053-770-2055, Email: misoyam@hanmail.net
Received: February 18, 2019,   Accepted: March 23, 2019,   Published online: March 30, 2019.
ABSTRACT
Objectives:
The purpose of this study was to assess the effects of Korean medicine for non-alcoholic fatty liver disease (NAFLD). We analyzed the result of randomized controlled trials (RCTs) that applied Korean medicine to NAFLD patients through meta analysis and systematic review.

Methods:
The key question was to the effects of Korean medicine for NAFLD patients according to the PICO-SD (participants, intervention, comparison, outcome, study design) and we included only RCTs. We searched 10 databases including NDSL, KMBASE, KISS, KISTI, KoreaMed, Koreantk, OASIS, Cochrane, Pubmed, EMBASE without a language restriction. We assessed risk of bias by Cochrane group's Risk of Bias tool.

Results:
The finally selected 12 RCTs were analyzed. Total number of participants was 1189 (male 719, female 470) as 684 and 505 in the oriental medicine group (i.e. herbal drugs, acupuncture, acupoint embedding therapy) and control group (conventional drugs, placebo), respectively. The meta analysis results of examining 7 RCTs comparing the therapeutic efficacy of herbal medicine with that of Western medicine showed statistically significant (p<0.05) differences in the efficacy evaluation, liver function test results, blood lipids, and TNF-α. Furthermore, the meta analysis results of investigating 3 RCTs comparing the therapeutic efficacy of herbal medicine with that of a placebo showed statistically significant (p<0.05) differences in the liver function test results, blood lipids, and waist circumference.

Conclusions:
The research showed that Korean medicine for NAFLD can be effective treatment. But more studies are required to enhance the level of evidence and we should report on safety.
Key words: non-alcoholic fatty liver disease, Korean medicine, systematic review, meta analysis
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