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The Journal of Internal Korean Medicine > Volume 40(1); 2019 > Article
The Journal of Internal Korean Medicine 2019;40(1): 1-12.
doi: https://doi.org/10.22246/jikm.2019.40.1.1
수컷 생쥐의 골다공증과 근위축에 대한 益智仁의 효과
김형준1, 안상현2, 박선영3
1세명대학교 부속 제천한방병원 부인⋅소아과
2세명대학교 한의과대학 해부학교실
3세명대학교 한의과대학 생리학교실
The Effects of Alpiniae Oxyphyllae Fructus on Osteoporosis and Muscle Dystrophy of Male Mice
Hyeong-jun Kim1, Sang-hyun Ahn2, Sun-young Park3
1Dept. of Gynecology, College of Korean Medicine, Se-Myung University
2Dept. of Anatomy, College of Korean Medicine, Se-Myung University
3Dept. of Physiology, College of Korean Medicine, Se-Myung University
Correspondence  Sun-young Park ,Tel: +82-43-649-1345, Email: blbee@semyung.ac.kr
Received: December 31, 2018,   Accepted: April 1, 2019,   Published online: March 30, 2019.
ABSTRACT
Objective:
To investigate the effect of Alpiniae oxyphyllae fructus (AOF) on the alleviation of musculoskeletal disorders caused by aging, we conducted experiments on osteoporosis and muscle atrophy.

Methods:
The experimental group was classified into a control group, aging-elicited (AE) group and AOF group. The control group comprised 8-week-old Institute of Cancer Research (ICR) mice. The AE and AOF groups were ICR mice at 50 weeks of age. For the AE group, 10 mL of distilled water was administered once a day for 180 days without any treatment. An AOF extract (0.54 g/kg) was dissolved in distilled water and administered to the mice in the AOF group once a day for 180 days.

Results:
In the experiment on the alleviation of osteoporosis, the distribution of glucosaminoglycan in the bone matrix of the femoral bone was increased in the AOF group; moreover, the osteocalcin (OCN) positive reaction was increased and 8-OHdG positivity was decreased. In addition, AOF positively decreased RANKL, positively increased OPG, and positively decreased MMP-3. Muscle fiber loss in the endomysium following muscle degeneration of the quadriceps was reduced more in the AOF group compared with the AE group, and caspase-3 positive responses were also decreased. In addition, the 8-OHdG and p-lkB positivity in the AOF group decreased compared with the AE group, and the Myo-D positivity increased.

Conclusion:
We found that increasing bone formation alleviates osteoporosis, and that reducing bone loss alleviates muscle atrophy by reducing muscle loss and increasing muscle development
Key words: Alpiniae oxyphyllae fructus, osteoporosis, muscle dystrophy, OPG, RANKL, Myo-D
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