|
|
The Journal of Internal Korean Medicine 2003;24(3): 579-587. |
| 육미지황탕 가 황인삼 추출물의 Cisplatin 유도 신장 독성 보호효과 |
|
|
| Beneficial Effect of Liuwei Dihuang Tang Jia Renshen Huangqi Extract on Cisplatin-Induced Kidney Toxicity in Rats |
| Jong-Bae Choi, Kyung-hwan Lee, Yong-Seung Kim |
| Department of Internal Medicine, Collage of Oriental Medicine, Dongshin University |
|
|
|
Published online: September 30, 2003. |
|
|
|
| ABSTRACT |
|
The prsent study was carried out to determine if Liuwei Dihuang Tang Jia Renshen Huangqi(P6) extract exerts beneficial effect against the renal failure in rats. P6 was selected in the basis of invigorating kidney-QI and premordial-QI which can eliminate pathogens. Rats were pretreated with P6 orally for 7 days, followed by cisplatin injection(5 mg/kg body weight). Cisplatin injection caused an increase in serum creatinine level, and BUN too. The main cause of cisplatin-induced renal failure was thought to be the increase of lipid peroxidation of renal tissues. And cisplatin administration reduced the activation of GSH and Na-K-ATPase. But P6 treatment exerts beneficial effect against the renal failure by decreasing serum level of creatinine and BUN. Na-K-ATPase activity in renal cortical tissues increased, too. These results indicate that lipid peroxidation plays a critical role in cisplatin-induced acute renal failure. P6 exerts the protective effect against acute renal failure induced by cisplatin, and its effect may be attributed to an antioxidant action. |
|
|
|
PDF Links
Full text via DOI 
Download Citation 
