Antibacterial effects of Corptis japonica against Helicobacter pylori

Shin, Jeong-In; Seo, Un-kyo

The Journal of Internal Korean Medicine > Volume 24(2); 2003 > Article

Original Article

The Journal of Internal Korean Medicine 2003;24(2): 269-282.

黃連의 Helicobacter pylori에 대한 항균 효과

Antibacterial effects of Corptis japonica against Helicobacter pylori

Jeong-In Shin, Un-kyo Seo

Department of Internal Medicine, College of Oriental Medicine, Dongguk University

Correspondence

Jeong-In Shin ,Tel: 031-710-3734, Fax: 031-710-3780, Email: shindoli@hanmail.net

Received: March 13, 2003, Accepted: May 2, 2003, Published online: June 30, 2003.

ABSTRACT

Water and ethanol extracts of 67 species of medicinal plants were tested to determine antimicrobial activity against Helicobacter pylori. Among them, the extracts of Coptis japonica showed the best antibacterial activity. The extract of C. japonica showed four major spots on TLC plate and the Rf values of the spots were 0.07, 0.13, 0.21 and 0.73, respectively. Except for the spot of Rf 0.73, other three spots inhibited the cell growth of H. pylori. As shown in HPLC analysis, three antimicrobial spots contain berberine, major antimicrobial substance of C. japonica. However, the spot of Rf 0.13 had higher activity than berberine. The concentrated water extract of three prescribed medicines related with C. japonica showed good antibacterial activity against H. pylori.

Key words: Helicobacter pylori, Coptis japonica, antibacterial activity, berberine