| 藿香正氣散이 家兎의 수축혈관에 미치는 影響 |
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| Effects of GwakHyangJungGiSan on the Arterial Contraction in Rabbit |
| Chang-Mo Koo1, Jung-Ki Sun1, Ho-Hyun Kim2, Chang-Gyu Nam3 |
1Department of Internal Medicine, Kwang-Dong Oriental Medicine Hospital
2Department of Physiology, College of Oriental Medicine, Semyung University
3Department of Circulatory Internal Medicine, College of Oriental Medicine, Semyung University |
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Received: March 8, 2003, Accepted: May 30, 2003, Published online: June 30, 2003. |
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| ABSTRACT |
Object:
This study was undertaken to define the mechanism of GwakHyangJungGiSan-induced relaxation in rabbit common carotid artery contracted by agonists.
Method:
In order to investigate the effect of GwakHyangJungGiSan on rabbit s contracted vascular ring detached from common carotid artery, vascular ring intact or damaged endothelium was used for the experiment using organ bath. To analyze the mechanism of GwakHyangJungGiSan-induced relaxation, GwakHyangJungGiSan extract was infused into contracted vascular ring which had been pretreated by pretreatment of indomethacin(IM), tetraethylammonium chloride(TEA), N -nitro- L-arginine(L-NNA).
Result:
GwakHyangJungGiSan blocks an inflow of Ca2+ and relaxes vascular ring by the action of Nitric oxide from endothelium. Consequently when GwakHyangJungGiSan is prescribed, a rise in blood pressure by the resistance of peripheral vessel may be controlled to some extent and so it is anticipated that hypertension, a disorder of blood flow from the vascular contraction and vascular disease will be treated well. |
| Key words:
GwakHyangJungGiSan, endothelium, hypertension, Nitric oxide |
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