| 생쥐의 B 세포에서 IgE의 분비와 Cytokine 생산에 대한 小靑龍湯의 效果 |
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| The Inhibitory Effects of SoCheongRyongTang(SCRT) on Cytokine Production and Secretion of IgE in Highly Purified Mouse B cells |
| Han-ho Bae, Joung Eun Lee, Young Ju Han, Yang-chun Park |
| Department of Internal Medicine College of Oriental Medicine, Daejeon University, Daejeon, Korea |
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Received: April 12, 2003, Accepted: June 16, 2003, Published online: June 30, 2003. |
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| ABSTRACT |
Objective :
We aimed to identify the inhibitory effects of SocheongRyoungTang on Cytokine Production and Secretion of IgE in Highly Purified Mouse B cells. This experiment was designed to investigate the effect of SoCheongRyongTang(SCRT) on Antiallergy.
Materials and Methods :
We measured the cytotoxic activity for cytokines transcript expression, production of IL-1β , IL-4, IL-6, IL-10, IFN-γ ,TNF-α , TGF-β proliferation of B cell in anti-CD40mAb plus rIL-4 plus HRF stimulated murine splenic B cells and histamine in anti-CD40mAb plus rIL-4 plus HRF stimulated mast cells.
Results:
1. SCRT increased the gene synthesis of IFN-γ (m-RNA), the appearance of IL-10, IFN-γ . 2. SCRT decreased the gene synthesis of IL-1β , IL-4, TGF-β (m-RNA) and the appearance of IL-1β , IL-4, TGF-β , IgE significantly.
Conclusion:
SCRT decreased the proliferation of B cell significantly. According to the above results, it is suggested that SCRT extract might be usefully applied for prevention and treatment of Allergic disease. |
| Key words:
SoCheongRyongTang, Cytokine, IgE, Antiallergy |
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