| 대식세포의 oxLDL 생성에 미치는 강활속단탕의 영향 |
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| Effects of KanghwalSokdantang(KS) on LDL Oxidation in Macrophage Cell |
| Seung-Ho Sun, Seong-Gyu Ko, Yong-Su Jeong |
| Department of Circulatory Internal Medicine, College of Oriental Medicine, Sangji University, Wonju-Si, Korea |
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Received: February 5, 2003, Accepted: May 3, 2003, Published online: June 30, 2003. |
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| ABSTRACT |
Objective :
As a link in chain of research to confirm the oriental medical prescription which has the anti-atherosclerosis effects, this research evaluated the effects on the macrophage-related factors by using KanghwalSokdantang(KS).
Methods :
In order to perform this research, we have evaluated the effects on the oxLDL formation from the macrophages, the nitric oxide formation, and the oxidation of macrophages. Thus, with this evaluation, we have investigated the applicapability on the artherosclerosis.
Results:
KanghwalSokdantang has showed a noticeable reduction of protein oxidation in the process of oxLDL formation, has remarkably restrained phospholipid peroxidation, an index to estimated the phospholipid oxidation and reduction that are formed in the process of macrophage s oxLDL formation, and has increased the nitrite concentration noticeably in the LDLdealing macrophages. By increasing the survival rate of macrophages, KanghwalSokdantang has restrained the cellular damages. KanghwalSokdantang is ineffective on the LDH outflow from damaged cells. 1㎍/㎖ KanghwalSokdantang sample has increased acid phosphatase activity remarkably.
Conclusion:
KanghwalSokdantang has the possibility to be used in the prevention and treatment of atherosclerosis, which is formed by the oxLDL formation of macrophages. |
| Key words:
oxLDL, macrophage, atherosclerosis, KanghwalSokdantang |
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