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The Journal of Internal Korean Medicine 2003;24(1): 94-103. |
| 桂枝茯丸, 少腹逐瘀湯, 桃紅四物湯이 메산지움세포 증식과
Fibronectin 합성에 미치는 影響 |
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| The Experimental Studies Of The Kaejibokryungwhan, Sobokchugeotang And Dohongsamultang On The Mesangial Cell Proliferation And Fibronectin Synthesis |
| Young-Ku Kwon, Young-Min Ahn, Se-Young Ahn, Ho-Kyung Doo |
| Department of 6th Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea |
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Received: December 28, 2002, Accepted: February 11, 2002, Published online: March 30, 2003. |
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| ABSTRACT |
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In order to investigate the effects of Kaejibokryungwhan, Sobokchugeotang and Dohongsamultang on mesangial cell proliferation and fibronectin synthesis, laboratory study was performed. The results are summarized as follows; 1. Mesangial cell proliferation was significantly decreased in the Kaejibokryungwhan group and the Dohongsamultang group compared with the Control group. In the Sobokchugeotang group, the mesangial cell proliferation activity was lesser than Control group, but it was statistically non-significant. In Kaejibokryungwhan group, the Sobokchugeotang group and Dohongsamultang group, mesangial cell proliferation was significantly decreased compared with the Hydrocortisone group 2. In the group, which contained fetal bovine serum, fibronectin synthesis was decreased in the Kaejibokryungwhan group, the Sobokchugeotang group and Dohongsamultang group compared with Control group, but the difference was statistically non-significant. In Kaejibokryungwhan group, Sobokchugeotang group and Dohongsamultang group, fibronectin was less decreased compared with that of Hydrocortisone group. 3. In the group, which contained fetal bovine serum, fibronectin synthesis was significantly decreased in Kaejibokryungwhan group and Sobokchugeotang group than those of Control group. In Dohongsamultang group, the fibronectin synthesis was decreased than Control group, but the difference was statistically non-significant. In Sobokchugeotang group, the fibronectin synthesis was decreased than Hydrocortisone group, but it was statistically non-significant. According to the above results, the mesangial cell proliferation and fibronectin systhesis could be reduced by Kaejibokryungwhan group significantly. |
| Key words:
瘀血, Kaejibokryungwhan, Sobokchugeotang, Dohongsamultang, Mesangial cell proliferation, Fibronectin synthesis |
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