| 酒傷에 응용되는 醒酒淸肝湯이 알코올대사 및 간장애에 미치는 영향 |
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| Effects of the Sungjuchunggan-tang (Xingjiuqinggan-tang) on alcoholic metabolism and alcoholic liver damages |
| Jin-Sung Kim, Seong-Kyu Park, Sang-Hyub Yoon, Bong-Ha Ryu, Ki-Won Ryu |
| Institute of Oriental Medicine, Kyunghee University, Seoul |
| Correspondence |
Jin-Sung Kim ,Tel: 02-958-8895, Fax: 02-958-9136, Email: oridoc@chol.com
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Received: December 11, 2002, Accepted: February 7, 2003, Published online: March 30, 2003. |
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| ABSTRACT |
Objectives:
The aim of this study was to investigate effects of the Sungjuchunggan-tang (Xingjiuqinggan-tang), which has been used for alcoholic diseases in Oriental medicine, on alcoholic metabolism and alcoholic liver damage.
Methods :
We evaluated the activities of alcohol dehydrogenase(ADH)and aldehyde dehydrogenase (ALDH), and measured the levels of AST, ALT, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid in serum of guinea pigs.
Results and Conclusions :
In this experiment, Sungjuchunggan-tang, Pharbitidis Semen and Puerariae Radix significantly suppressed the activity of ADH which is a precursor enzyme of acetaldehyde. Sungjuchunggan-tang and Pharbitidis Semen significantly suppressed the activity of ALDH, which is a catabolic enzyme, and increased its level. Due to alcohol consumption, level of ALT and AST were significantly reduced. These experimental results suggest that Sungjuchunggan-tang and Pharbitidis Semen inhibit the formation of acetaldehyde in the metabolism of alcohol, and affect the recovery of weakened liver functions caused by alcohol. |
| Key words:
Sungjuchunggan-tang(Xingjiuqinggan-tang), Pharbitidis Semen, Puerariae Radix, ADH, ALDH |
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