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The Journal of Internal Korean Medicine 2003;24(1): 55-67. |
舟車丸이 CCl4 및 d-galactosamine으로 유발된 흰쥐의 肝損傷에 미치는 영향 |
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Protective effects of Jucha-whan on liver injury of guinea pigs induced by CCl4 and d-galactosamine |
Eun Ju Choi, Jae Chun Kang |
1Graduate School of Oriental Medicine, Sangji University 2Department of Internal Medicine, College of Oriental Medicine, Sangji University |
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Received: October 11, 2002, Accepted: December 20, 2002, Published online: March 30, 2003. |
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ABSTRACT |
Objective : In order to investigate the curative effect of Jucha-whan on the protective liver of guinea pigs induced by CCl4 and d-galactosamine, serum transaminase(GOT, GPT), lactic dehydrogenase(LDH), alkaline phosphatase(ALP), glutathione S-transferase(GST), superoxide dismutase(SOD) were used to measure enzyme activities and lipid peroxide level.
Method: The subject animals were divided into 5 groups; a control group(untreated), a subject group(administered with 0.9% Saline solution), a sample I (500 mg/kg administered), sample II group (1000 mg/kg administered), positive control group(administered with 200 mg/kg silymarine).
Result: The inhibitory effects on the serum GOT, LDH, ALP, SOD and Lipid peroxide level activities in protective liver of mice induced by CCl4 were noted both in the sample I group and sample II. The inhibitory effects on the serum GPT activities in protective liver of guinea pigs induced by CCl4 were noted in sample II group, but it was not noted in the sample I . The inhibitory effects on the GST activities in protective liver of guinea pigs induced by CCl4 were not noted in both sample I and sample II group . The inhibitory effects on the serum GOT, GPT activities in protective liver of guinea pigs induced by dgalactosamine were noted in both sample I and sample II, but it was not recognizable statistically. The inhibitory effects on the serum LDH activities in protective liver of guinea pigs induced by d-galactosamine were noted in sample II , but it was not noted in sample I group.
Conclusion: According to the above results, it is considered that Jucha-whan has treatment effects on liver injury in guinea pigs induced by CCl4 and d-galactosamine. So it is required to study about the actions of mutual relation of medicines and patho- mechanism through experiment. |
Key words:
Jucha-whan, CCl4 |
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