Two Cases of Middle Cerebral Artery Stenosis with Homozygous Mutation of Vascular Endothelial Growth Factor(VEGF) Gene.

Seo, Al-An; Yang, Tae-Kyu; Yeo, In-Young; Kim, Hyung-Do; Jung, Woo-Sang; Park, Jung-Mi; Choi, Byung-Ok

The Journal of Internal Korean Medicine > Volume 23(4); 2002 > Article

Original Article

The Journal of Internal Korean Medicine 2002;23(4): 741-746.

Vascular Endothelial Growth Factor Gene 의 Homozygous Mutation 을 보인 MCA stenosis 2례

서알안¹, 양태규¹, 여인영¹, 김형도¹, 정우상¹, 박정미¹, 최병옥²

¹포천중문의과대학 분당 차한방병원 한방내과
²포천중문의과대학 분당 차병원 신경과

Two Cases of Middle Cerebral Artery Stenosis with Homozygous Mutation of Vascular Endothelial Growth Factor(VEGF) Gene.

Al-An Seo¹, Tae-Kyu Yang¹, In-Young Yeo¹, Hyung-Do Kim¹, Woo-Sang Jung¹, Jung-Mi Park¹, Byung-Ok Choi²

¹Department of Oriental Internal Medicine, Collage of Medicine, Pochon CHA University
²Department of Neurology, Collage of Medicine, Pochon CHA University

Correspondence

Al-An Seo ,Tel: 031-780-6050, Fax: 031-780-6120, Email: jsloveaa@freechal.com

Received: September 13, 2002, Accepted: October 24, 2002, Published online: December 30, 2002.

ABSTRACT

Vascular Endothelial Growth Factor(VEGF) induces angiogenesis and is expressed in higher than normal concentrations in penumbra patients after acute ischemic stroke. Considering that 936 C/T allele represents lower plasma VEGF level, the VEGF genetic mutation seems to affect the occurrence and prognosis of stroke by forming intimal thickening and collateral circulation. We were to report two ischemic stroke patients having middle cerebral artery stenosis with the VEGF gene mutation.

Key words: vascular endothelial growth factor, atherosclerosis, genetic mutation