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The Journal of Internal Korean Medicine > Volume 23(2); 2002 > Article
Original Article
The Journal of Internal Korean Medicine 2002;23(2): 191-201.
육미치황탕이 흰쥐의 뇌손상 회복에 미치는 영향
김용진1, 김방울1, 김경선1, 전홍열1, 강화정1, 김정상2, 홍석1
1동신대학교 한의과대학 심계내과학교실
2동신대학교 한의과대학 해부학교실
Effects of Yukmijihwang-tang to Recover the Brain Damage of Mice
Yong-Jin Kim1, Bang-Oul Kim1, Kyung-Sun Kim1, Hong-Yeol Jeon1, Hwa-Jeong Kang1, Jeong-Sang Kim2, Seok Hong1
1Dept. of Internal Medicine, College of Oriental Medicine Dongshin University
2Dept. of Anatomy, College of Oriental Medicine Dongshin University
Correspondence  Yong-Jin Kim ,Tel: 062-350-7282, Fax: 062-366-1882, Email: riv2000@hanmail.net
Received: July 10, 2002,   Accepted: July 31, 2002,   Published online: June 30, 2002.
ABSTRACT
Objectives:
This study was designed to investigate the effects of Yukmijiwhang-tang on contusion of the mice induced with medicine.

Methods :
I observed the effects of light and electron microscopes, and examined hematological changes and VEGFimmunohistochemistry.

Results:
Hematology: Leukocytes were increased significantly in a control group of mice compared with the experimental group. Light microscope : A few neurons were condensed in the 7-day experimental group, but condensed remarkedly in the 3- day control group. Most glial cells were observed in the 3-day experimental group. Edema and dilatation of vessels occurred significantly in the 3-day control group, and these results occurred weakly in the 7-day experimental group. VEGF-immunohistochemistry : VEGF-immunohistochemical reactivity for the glial cells was the highest in the 3-day experimental group, and immunoreactivity for the vessels and neurons highly increased in the 7-day experimental group. Electron microscope : In the 3-day control group, protoplasmic astrocytes concerned with angiogenesis contained weakly developed rough endoplasmic reticulum, and a few of glial filaments were observed. In the 7-day experimental group, the bundles of glial filaments were found in the cytoplasmic process of astrocytes.

Conclusion:
medication using Yukmijiwhang-tang of mice contused by medical stress is highly effective in inflamatory response, curing cell damage and angiogenesis.
Key words: Yukmijiwhang-tang, VEGF-immunohistochemistry, angiogenesis.
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