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The Journal of Internal Korean Medicine > Volume 22(2); 2001 > Article
The Journal of Internal Korean Medicine 2001;22(2): 215-222.
조각자의 향돌연변이 및 항산화 활성에 관한 연구
이신규, 신정인, 서운교, 정지천
동국대학교 한의과대학 내과학교실
A Study on Activities of Antioxidant and Antimutagenecity of the Extracts from Gleditsia sinensis
Shin-Kyu Lee, Jeong-In Shin, Un-Kyo Seo, Ji-Cheon Jeong
Department of Internal Medicine, College of Oriental Medicine, Dongguk University
Correspondence  Jeong-In Shin ,
Received: July 18, 2001,   Accepted: August 6, 2001,   Published online: June 30, 2001.
ABSTRACT
Against the mutagen MNNG and NOPD with SOS chromotest, the antigenotoxic activity of MeOH-soluble extract was much more effective than that of the water-soluble one. When the extract was added to the certain concentration, the antigenotoxic acivity was enhanced. Against the mutagen NOPD with Ames test, the antimutagenic activity of MeOH-soluble extract was better than that of the water-soluble one. The 60.4% of the inhibition ratio for the revertant colony-forming unit was shown at 5mg of MeOH-soluble extract per plate. Antimutagenecity test with SOS chromotest and Ames test were performed using water-soluble and MeOH-soluble extracts from of Gleditsia sinensis. The antioxidant activity of MeOH-soluble extract with the NBT method was higher than that of the water-soluble one.
Key words: MNNG and NOPD, antimutagenic activity, Gleditsia sinensis, antioxidant activity
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