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The Journal of Internal Korean Medicine > Volume 22(2); 2001 > Article
The Journal of Internal Korean Medicine 2001;22(2): 199-205.
사향소합원이 정상인의 뇌혈류역학에 미치는 영향
류순현, 구본수, 김성환, 문상관, 조기호, 김영석, 배형섭, 이경섭
경희대학교 한의과대학 심계내과학교실
Effects of Sahyangsohap-won on Cerebral Hemodynamics in Healthy Subjects
Soon-Hyun Ryu, Bon-Soo Koo, Sung-Hwan Kim, Sang-Kwan Moon, Ki-Ho Cho, Young-Suk Kim, Hyung-Sup Bae, Kyung-Sup Lee
Department of Circulatory Internal Medicine, College of Oriental Medicine,Kyunghee University
Correspondence  Soon-Hyun Ryu ,
Received: July 21, 2001,   Accepted: August 27, 2001,   Published online: June 30, 2001.
Background and Purpose :
Transcranial doppler ultrasonography(TCD) is a noninvasive and nonradioactive technique for evaluation of the hemodynamics in large cerebral vessels. Sahyangsohap-won(SS) has been considered to be effective for the treatment of various disease, especially cerebrovascular, cardiovascular, and psychosomatoform disorders. But, there is no study about the effect of SS on the cerebral hemodynamics in humans. The aim of this study was to assess the effect of SS on the changes in cerebral hemodynamics and the dose-dependant effect by using TCD.

Subjects and Methods :
30 healthy subjects were randomly divided into three group: group 1 took no drug, group 2 took SS one pill, and group 3 took SS 2 pills. Changes in the mean blood flow velocity(MBFV) and pulsatility index(PI) in the middle cerebral artery were evaluated by means of TCD. We obtained hypercapnia with breath-holding and evaluated cerebrovascular reactivity with the breath-holding index(BHI). Systolic blood pressure(SBP), diastolic blood pressure(DBP), and heart rate(HR) were measured by means of ambulatory blood pressure monitoring. In group 2 and group 3, the evaluations were performed during the baseline and were repeated at 20, 40, and 60 minutes after SS administration. In group 1, the evaluation was performed at corresponding time intervals.

In mean values of MBFV, PI, SBP, DBP, and HR, no stastically significant differences were found between the 3 groups. However, BHI values were significantly lower in groups 2 and 3 than in group 1 at 40 minutes after SS administration(P<0.05, group 1 vs group 2, group 1 vs group 3 by post-hoc analysis: Scheffe s test) but in dose-dependant effect, there was no difference between group 2 and group 3.

These results suggest that SS can decrease vascular resistance in cerebral small arteries or arterioles and enhance their distensibility. Further studies on larger numbers of subjects are needed to confirm these effects and the dose-dependant effects.
Key words: Sahyangsohap-won, Hemodynamics, Transcranial doppler ultrasonography(TCD), Breath-holding index(BHI)
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