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The Journal of Internal Korean Medicine > Volume 22(2); 2001 > Article
The Journal of Internal Korean Medicine 2001;22(2): 175-181.
난소절제흰쥐의 골대사에 미치는 골쇄보의 영향
김광진, 정지천
동국대학교 한의과대학 내과학교실
Effects of Rhizoma Davalliae on Bone Metabolism in Ovariectomized Rats
Kwang-Jin Kim, Ji-Cheon Jeong
Department of Internal Medicine, College of Oriental Medicine, Dongguk University
Correspondence  Ji-Cheon Jeong ,
Received: July 3, 2001,   Accepted: August 30, 2001,   Published online: June 30, 2001.
ABSTRACT
Objectives:
This study was undertaken to study the action mechanism of Rhizoma Davalliae (RD) at parameter related to regulating bone density.

Methods :
We measured alkaline phosphatase activity and the contents : calcium, hydroxyproline, osteocalcin, calcitonin, and parathyroid hormone after the ovariectomized rats had been treated with RD for 30 days.

Results:
The following changes occurred: First, the serum calcium content and the calcitonin content, which decreased in ovariectomized rats, increased with RD treatment. Second, the serum alkaline phosphatase activity, the parathyroid hormone ativity, the osteocalcin content, the urinary calcium content, and the hydroxyprolin content-which increased in ovariectomized rats-decreased with RD treatment.

Conclusions:
These results show that RD treatment can recover abnormal calcium metabolic process by sex hormone inequality, promoting bone formation and inhibiting bone absorption.
Key words: Rhizoma Davalliae, esterogen, calcium, ovariectomy, bone formation, bone absorption
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