Effects of <i>Cordyceps Sinensis</i> on Antioxidation in the Livers of Hydrocortisone Acetate-Treated Rats.

Park, Jong-Hyuck; Lee, Gu-Hyong; Min, Gun-Woo; Yoon, Cheol-Ho; Seo, Un-Kyo; Jeong, Ji-Cheon; Han, Yeong-Hwan; Shin, Uk-Seob

The Journal of Internal Korean Medicine > Volume 22(1); 2001 > Article

Original Article

The Journal of Internal Korean Medicine 2001;22(1): 63-71.

동충하초가 hydrocortisone으로 유발시킨 양허 동물모형에서 항산화 작용에 미치는 영향

박종혁¹, 이구형¹, 민건우¹, 윤철호¹, 서운교¹, 정지천¹, 한영환², 신억섭³

¹동국대학교 한의과대학 내과학교실
²동국대학교 자연과학대학 생물학과
³동국대학교 의료원 약제과

Effects of Cordyceps Sinensis on Antioxidation in the Livers of Hydrocortisone Acetate-Treated Rats.

Jong-Hyuck Park¹, Gu-Hyong Lee¹, Gun-Woo Min¹, Cheol-Ho Yoon¹, Un-Kyo Seo¹, Ji-Cheon Jeong¹, Yeong-Hwan Han², Uk-Seob Shin³

¹Department of Internal Medicine, College of Oriental Medicine, Dongguk University
²Department of Biology, College of Natural Science, Dongguk Univ
³Department of Pharmmacy, Dongguk Medical Center

Correspondence

Jong-Hyuck Park ,

Received: May 10, 2001, Accepted: June 12, 2001, Published online: March 30, 2001.

ABSTRACT

Objectives:
Cordyceps Sinensis (CS) was tested for the effects of antioxidant enzymes and lipid peroxidation in the liver.

Methods :
We measured the changes in body weight, enzyme activity, lipid peroxide and the death rate in the hydrocortisone acetate-treated rats.

Results:
In vitro, CS didn t effect levels of lipid peroxide, the activities, and the ratio of type conversion of xanthine oxidase. In the hydrocortisone acetate-treated rats, lipid peroxide, the activities, the ratio of type conversion of xanthine oxidase, and the death rate all increased. But, glutathione peroxidase and superoxide dismutase decreased. In vitro, after CS was administered to hydrocortisone acetatetreated rats, the levels of lipid peroxide in the liver, and the death rate decreased. However, the activities, and the ratio of type conversion of xanthine oxidase decreased. The body weight, glutathione peroxidase, and superoxide dismutase in+creased. The effects of Sinensis Cordyceps Broth did better than the effects of Sinensis Cordyceps Mycelia.

Conclusions:
These results suggest that CS decrease the activities of free radical generating enzymes which form lipid peroxide and increase the activities of oxygen free radical scavenging enzymes.

Key words: Cordyceps Sinensis Broth, hydrocortisone, lipid peroxidation, Antioxidation, Cordyceps Sinensis Mycelia