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The Journal of Internal Korean Medicine > Volume 22(1); 2001 > Article
The Journal of Internal Korean Medicine 2001;22(1): 53-61.
삼자산이 흰쥐 음경조직의 Nitric Oxide synthase 활성 및 과산화지질에 함량에 미치는 영향
민건우1, 위영택1, 박종혁1, 윤철호1, 정지천1, 신억섭2
1동국대학교 한의과대학 내과학교실
2동국대학교 의료원 약제과
Effects of the Extract of Samjasan on the Nitric Oxide Synthase Activity and the Level of Lipid Peroxide in Penis of Rats.
Gun-Woo Min1, Young-Taek We1, Jong-Hyuck Park1, Cheol-Ho Yoon1, Ji-Cheon Jeong1, Uk-Seob Shin2
1Department of Internal Medicine, College of Orietal Medicine, Dongguk Univ
2Dept. of Pharmacy, Dongguk Medical Center
Correspondence  Gun-Woo Min ,
Received: May 10, 2001,   Accepted: June 5, 2001,   Published online: March 30, 2001.
ABSTRACT
Objectives:
The following are the results of the experimental studies of Samjasan (SJS) extract on the nitric oxide synthase (NOS) activity and the level of lipid peroxide in the penises of rats.

Methods :
Cnidii Fructus, Cuscutae Semen, Schizandrae Fructus constitute SJS. 150 g of crushed crude drug was extracted with methyl alcohol, under reflux, for 24 hours, three times; the total extractive was evaporated under reduced pressure to give 28.6 g.

Results:
In vitro, the SJS extract didn t effect the activity of NOS. However, the SJS extract decreased the activities, the ratio of type conversion of xanthine oxidase, the levels of lipid peroxide. In vitro, after administration of the SJS extract to rats, the activities and ratio of type conversion of xanthine oxidase decreased, but the activity of NOS and the content of nitrite increased. Also, the levels of the superoxide anion radical and lipid peroxide decreased in the penises of rats. But, after administration of the SJS extract to rats, the levels of glutathione did not increase. The effects of the SJS extract did better as the dosage and the length of treatment increased.

Conclusions:
These results suggest that the SJS extract decreases the activities of free radical generating enzymes which form lipid peroxide and increases the NOS activity in the penises of rats. Therefore, the SJS extract is capable of improving of sexual ability in rats.
Key words: Samjasan extract, nitric oxide synthase activity, lipid peroxide.
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