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The Journal of Internal Korean Medicine > Volume 22(1); 2001 > Article
The Journal of Internal Korean Medicine 2001;22(1): 45-52.
인삼이 Cyclosporin A로 유발된 백서의 신손상에 미치는 영향
서호석, 한양희, 박종형, 전찬용, 김동우, 박세기, 이청정혜, 고승희, 고재철, 최유경, 백은기, 홍의실, 박지윤
경원대학교 내과학교실
A Study on the effects of Ginseng Radix extract on rat with nephrotoxicity
Ho-Suk Seo, Yang-Hi Han, Jong-Hyung Park, Chan-Yong Jun, Dong-U Kim, Se-Gi Park, Chung-Jung-Hye Lee, Seung-Hi Go, Jae-Chul Go, You-Kyung Choi, Eun-Gi Baek, Ui-Sil Hong, Ji-Yun Park
Department of Internal Medicine, College of Oriental Medicine, Kyung-Won University
Correspondence  Seung-Hi Go ,
Received: April 27, 2001,   Accepted: June 14, 2001,   Published online: March 30, 2001.
ABSTRACT
Purpose:
This study is to find out the Ginseng Radix extract on rats nephrotoxicity when the rates were induced by Cs A.

Methods :
The experimental animals were divided into 3 groups and treated as follows: nothing was given to Sample A, Sample B was given normal saline after an I.V. injection of Cs A, and Sample C was given Ginseng Radix extract after a Cs A injection. The groups were observed for 14 days. After the prescription of the medicines, the following levels were tested: serum BUN, creatinine, total protein, sodium, potassium, and chloride ions.

Results:
1. Changes in serum level. The levels of GPT, GOT, and BUN were significantly reduced in the experimental group when compared with those of the control group. The total protein level showed significant elevation when compared with those of the control group. The chloride level in the serum in the sample group was insignificantly reduced. The creatinine level was insignificantly increased. The Potassium level decreased, mildly. The Sodium and The Potassium levels in the serum in the sample group showed insignificantly lower levels than those of the control group. 2. Changes in the urine level. Urine specific gravity showed a significant increase, on the 14th day, in the experimental group when compared with that of the control group. The urinary ceatinine levels showed and insignificant increase, followed by an insignificant decrease.
Key words: Cyclosporin A, nephrotoxicity, hepatoxicity
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