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The Journal of Internal Korean Medicine > Volume 21(4); 2000 > Article
The Journal of Internal Korean Medicine 2000;21(4): 543-548.
Chinse Herb Nephropathy 란 용어는 올바른 것인가?
이병철, 최기림, 이진신, 장원만, 안영민, 안세영, 두호경
경희대학교 한의과대학 신계내과학교실
Is the term of Chinese Herb Nephropathy proper?
Byung-Cheol Lee, Ki-Lim Choi, Jin-Sin Lee, Won-Man Jang, Young-Min Ahn, Se-Young Ahn, Ho-Kyung Doo
Dept. of 6th Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Correspondence  Byung-Cheol Lee ,
  Published online: November 30, 2000.
After Vanherweghem J-L reported the rapidly progressive interstitial renal fibrosis that developed in patients taking the slimming preparation compounded with chinese Herb in Belgium 1993, Chinese Herb Nephropathy(CHN) has become known as a new renal disease. CHN is described as the decrease of urinary renal enzyme,neutral endopeptidase(NEP), N-acetyl- -Dglucosaminidase(NAG), increase of urinary low molecular protein, α1-microglobulin, β2-microglobulin, clara cell protein(CC16), retinol-binding protein(RBP) in clinical findings, and the proximal tubular atrophy, interstitial fibrosis, urothelial atrophy, glomerular sclerosis in histology. Because CHN was caused by Chinese herb contained in slimming preparation, western medical doctors have thought that all Herb medicine might have caused renal disease and prohibit the taking of any Herb medicine. However, CHN was actually caused by the aristolochic acid contained in some Herb medicines, Aristolochia manshuriensis, Aristolochia fang chi, which is the substitutions of Akebia quinata, Stephania tetrandra has being used in clinical. Aristolochia manshuriensis, Aristolochia fang chi were different with Akebia quinata, Stephania tetrandra in botany, and it have not been classified with medicines in Oriental medicine. That is, the aristolochic acid, not Herb medicines, causes CHN. So, Chinese Herb Nephropathy should be changed to Aristolochic acid Nephropathy.
Key words: Chinese Herb Nephropathy, Aristolochic-acid nephropathy
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