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The Journal of Internal Korean Medicine > Volume 36(4); 2015 > Article
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The Journal of Internal Korean Medicine 2015;36(4): 507-517.
후박 에탄올 추출물의 불안 및 인지기능에 대한 효과
이현기, 이언정
원광대학교 한의과대학 내과학교실
Effects of Ethanol Extract from Magnolia Officinalis on Anxiety and Cognitive Function
Hyun-ki Lee, Un-jung Lee
Dept. of Internal Medicine, College of Oriental Medicine, Won-Kwang University
Correspondence  Un-jung Lee ,Tel: 063-270-1065, Fax: 063-270-1199, Email: ejlee1016@hanmail.net
Received: November 12, 2015,   Accepted: December 29, 2015,   Published online: December 31, 2015.
ABSTRACT
The bark of Magnolia Officinalis has been used in traditional oriental medicine to treat a variety of mental disorders including anxiety and depression. The purpose of this study was to examine the effect of M. officinalis ethanol extract on stress-induced alterations in learning and cognitive function using a passive avoidance test (PAT) and also on anxiety-related behavior using the elevated plus-maze test (EPM) in female rats . The degree of Tyrosine hydroxylase (TH) in the region of the ventral tegmental area (VTA) and the locus coeruleus (LC) was measured using an immunohistochemical method. Corticosterone concentrations in serum were also measured. The ethanol extract from Magnolia Officinalis was orally administered to female rats 30 minutes before evaluating their immobilization stress and anxiety-related behavior using an elevated plus-maze test and a passive avoidance test.
Time spent in the open arms of the EPM increased in the M. officinalis-treated group compared with that of the saline-treated control group. In the passive avoidance test, the memory and cognitive function improved in the M. officinalis extract-treated group. M. officinalis extracts reduced elevated corticosterone concentrations in serum. Also, stress-induced TH increases were suppressed in the M. officinalis extract-treated group in the LC and the VTA region.
These results suggest that M. officinalis might prove to be an effective anxiolytic anti-stress agent.
Key words: Magnolia Officinalis, anxiety, stress, elevated plus-maze test, passive avoidance test, tyrosine hydroxylase, locus coeruleus, ventral tegmental area, corticosterone
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