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The Journal of Internal Korean Medicine > Volume 36(4); 2015 > Article
The Journal of Internal Korean Medicine 2015;36(4): 447-457.
黃柏이 비만 유발 mouse의 대사기능에 미치는 영향
마영훈1, 김효재1, 한양희1, 김한옥2, 오재선3
1동신한방병원 한방내과
2동서한방병원 한방내과
3동신대학교 부속 목포한방병원 한방내과
Effects of Cortex Phellodendri on the Metabolic Function in Experimental Mouse Model of Obesity
Young-hoon Ma1, Hyo-jae Kim1, Yang-hee Han1, Han-ok Kim2, Jae-seon Oh3
1Dept. of Oriental Internal Medicine, Dong-Shin Oriental Medical Hospital
2Dept. of Oriental Internal Medicine, Dongseo Oriental Medical Hospital
3Dept. of Oriental Internal Medicine, Dong-Shin University Mok-Po Oriental Medical Hospital
Correspondence  Yang-hee Han ,Tel: 02-2640-2931, Fax: 02-2640-2727, Email: omdhyh@hanmail.net
Received: September 30, 2015,   Accepted: December 29, 2015,   Published online: December 31, 2015.
ABSTRACT
Objectives:
This study was undertaken to investigate how Cortex Phellodendri affects metabolic functional change in an experimental rat model of obesity.

Methods:
An obesity model was induced in a C57BL/6 mouse with a high-fat diet. Mice were divided into three groups (n=6) of normal diet, high-fat diet (=control), and high-fat diet with Cortex Phellodendri. After 12 weeks, we measured the three mice groups’ body weight, FBG, FBI, HOMA-IR, OGTT, the weight of epididymal fat and liver, the percentage of ATM, and the gene expression of TNF-α, IL-10, and CD68.

Results:
Cortex Phellodendri significantly reduced blood glucose and oral glucose tolerance levels. It also reduced ATM numbers and TNF-α and CD68 gene expression and increased IL-10 gene expression.

Conclusions:
This study suggests that Cortex Phellodendri normalized the blood glucose and reduced the expression of inflammatory markers. However, with respect to other indicators of metabolic function in obesity, there were no significant results.
Key words: Cortex Phellodendri, obesity, blood glucose, anti-inflammatory, metabolic fuction
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