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The Journal of Internal Korean Medicine > Volume 37(1); 2016 > Article
The Journal of Internal Korean Medicine 2016;37(1): 109-134.
감기 임상시험 가이드라인 제정을 위한 최신 임상시험 연구 분석
김관일1,3, 이호정2,3, 이범준1, 정희재1, 정승기1, 이준희2,3
1경희대학교 한의과대학 폐계내과학교실
2경희대학교 한의과대학 대학원 임상한의학과교실
3경희대학교한방병원 한의약임상시험센터
Analysis of Recent Clinical Studies to Establish Korean Herbal Medicine Clinical Trial Guidelines for the Common Cold
Kwan-il Kim1,3, Ho-jung Lee2,3, Beom-joon Lee1, Hee-jae Jung1, Sung-ki Jung1, Jun-hee Lee2,3
1Division of Allergy, Immune & Respiratory System, Department of Internal Medicine, College of Korean Medicine, Kyung-Hee University
2Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University
3Korean Medicine Clinical Trial Center, Kyung-Hee University Korean Medicine Hospital
Correspondence  Jun-hee Lee ,Tel: +82-2-958-9280 , Fax: +82-2-958-9234, Email: ssljh@daum.net
Received: March 7, 2016,   Accepted: April 4, 2016,   Published online: March 31, 2016.
ABSTRACT
Objectives:
The aim of this study was to help develop a guideline for the common cold. We searched recent clinical studies of the common cold in Western medicine and reviewed their objectives, inclusion and exclusion criteria, primary outcome, secondary outcome, and assessment tools to establish evidenced-based guideline.

Methods:
We searched electronic databases (Cochrane Library, MEDLINE, EMBASE) to identify eligible randomized controlled trials (RCTs) about the common cold for the last 10 years. We included 29 RCTs and showed their research summary via their objectives, participants, interventions, control, treatment duration, and results. We also analyzed the definition of the common cold presented in the article, inclusion and exclusion criteria, primary and secondary outcomes, and assessment tools.

Results:
We reported the aforementioned areas in detail. At first, the definition of the common cold was confused across the articles. Second, herbal medication clinical trials for the common cold have been extensively studied recently. Third, the eligibility criteria frequently included the Jackson Symptom score. Fourth, validated assessment tools (i.e., the Wisconsin Upper Respiratory Symptom Survey-21) have only been used in a few recent studies.

Conclusions:
Our research will be helpful to establish Korean herbal medicine clinical trial guidelines for the common cold.
Key words: common cold, randomized controlled trial, review
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