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The Journal of Internal Korean Medicine > Volume 37(1); 2016 > Article
The Journal of Internal Korean Medicine 2016;37(1): 8-15.
비글견을 이용한 GST 추출물의 단회 경구투여 용량증가 독성시험
이철화1, 양원경1,2, 정인철3, 진미림2,4, 김승형2, 박양춘1,2
1대전대학교 한의과대학 내과학교실
2대전대학교 동서생명과학연구원
3대전대학교 한의과대학 신경정신과학교실
4대전대학교 한의과대학 약리학교실
A Single Oral Dose Toxicity Test of GST in Beagle Dogs
Chul-wha Lee1, Won-kyung Yang1,2, In-chul Jung3, Mi-rim Jin2,4, Seung-hyeong Kim2, Yang-chun Park1,2
1Dept. of Internal Medicine, College of Korean Medicine, Dae-Jeon University
2Institute of Traditional Medicine and Bioscience, Dae-Jeon University
3Dept. of Neuropsychology, College of Korean Medicine, Dae-Jeon University
4Dept. of Pharmacology, College of Korean Medicine, Dae-Jeon University
Correspondence  Yang-chun Park ,Tel: 042-470-9490, Fax: 042-470-9486, Email: omdpyc@dju.kr
Received: January 8, 2016,   Accepted: March 28, 2016,   Published online: March 31, 2016.
To provide information on the safety of GST (Gami-Sasangja-tang), we carried out a single oral dose-increasing toxicity test of GST in beagle dogs. Materials and

Six beagle dogs (three males and three females) were randomly assigned to two groups (experimental group: n=4, control group: n=2). The experimental group (two males, two females) was given oral doses of GST in increasing order (1,250, 2,500, and 5,000 mg/kg) at three-day intervals. After administration, the participants’ mortality, clinical signs, and body weight changes were monitored for two weeks. After two weeks, all dogs were sacrificed for autopsy.

Temporary vomiting was observed according to increasing dosage (n=1, 250 mg/kg; n=4, 2,500 and 5,000 mg/kg). Transient diarrhea was observed on the second and third dosing day (n=1, 2,500 mg/kg; n=2, 5,000 mg/kg). Temporary salivation was noted on the third dosing day (n=3, 5,000 mg/kg). Compound-colored stool was observed in all dogs fed the GST on all dosing days and also on the following days. We found no mortality and no abnormalities in the clinical signs, body weight, and gross findings in any of the dogs tested.

The maximum tolerated dose was over 5,000 mg/kg for both male and female dogs.
Key words: GST (Gami-Sasangja-tang), safety, single oral dose-increasing toxicity, beagle dogs
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