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The Journal of Internal Korean Medicine > Volume 36(3); 2015 > Article
The Journal of Internal Korean Medicine 2015;36(3): 236-251.
감기 치료 빈용 처방 구성 약물의 효능 연구
김동현, 안현진, 강순성, 이범준, 정승기, 정희재
경희대학교 한의과대학 폐계내과학교실
Efficacy of 20 Select Herbs Against Common Cold
Dong-hyun Kim, Hyun-jin Ahn, Shuen-cheng Chiang, Beom-joon Lee, Sung-ki Jung, Hee-jae Jung
Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University
Correspondence  Hee-jae Jung ,Tel: 02-958-9147, Fax: 02-958-9148, Email: hanfish@khmc.or.kr
Received: July 9, 2015,   Accepted: September 24, 2015,   Published online: September 30, 2015.
ABSTRACT
Objectives:
To investigate the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines to test their efficacy in common cold treatment.

Methods:
For all experiments, the herbal medicines were extracted with 80% ethanol and freeze-dried. To determine the anti-oxidative properties, we tested DPPH-free radical-scavenging activity and xanthine oxidase inhibitory activity. To determine anti-inflammatory and analgesic potential, we investigated acetic acid-induced vascular permeability and writhing test in ICR mice. For anti-pyretic activities, an LPS-induced pyrexia study was conducted in rabbits. To evaluate the anti-histamine activity, we examined compound 48/80-induced systemic anaphylaxis in ICR mice and the release of β -hexosaminidase on rat basophilic leukemia (RBL-2H3) cells.

Results:
Ephedrae herba, Forsythiae fructus, Cinnamomi ramulus, and Cimicifugae rhizomeowed potent free-radical scavenging activities. Gentianae macrophyllae radix inhibited acetic acid-induced vascular permeability. schizonepetae spica and Cimicifugae rhizome inhibited acetic acid. Cinnamomi ramulus and Angelicae decursivae radix inhibited LPS-induced pyrexia. Angeliace dahuricae radix and Asari radix inhibited compound 48/80. Scutellariae radix, Cinnamomi ramulus, Ephedrae herba, and Zingiberis rhizoma crudus potently inhibited the release of β-hexosaminidase.

Conclusions:
We examined the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines; Codonopsis pilosulae radix, Zingiberis rhizoma crudus, and Cinnamomi ramulus showed novel efficacy. These results suggest that some of herbal medicines may be very effective in treating common cold.
Key words: common cold, anti-oxidative, anti-inflammatory, analgesic activities, anti-pyretic, anti-histamine
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