| 八正散이 Estradiol로 유도한 백서의 만성 비세균성 전립선염에 미치는 효과 |
| 이승욱1, 나현영1, 유정화1, 안영민1, 안세영1, 김영옥2, 이병철1 |
1경희대학교 한의과대학 신계내과학교실
2농촌진흥청 국립원예특작과학원 |
| Effects of Paljeong-san (八正散, Bazheng-san) on Chronic Nonbacterial Prostatitis
Induced in Rats by Estradiol |
| Seung-wook Lee1, Hyun-young Na1, Jeong-hwa Yoo1, Young-min Ahn1, Se-young Ahn1, Young-ock Kim2, Byung-cheol Lee1 |
1Dept. of Internal Medicine, College of Korean Medicine, Kyung-Hee University
2Dept. of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration |
| Correspondence |
Byung-cheol Lee ,Tel: 02-958-9182, Fax: 02-958-9158, Email: hydrolee@korea.com
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Received: June 2, 2015, Accepted: June 23, 2015, Published online: June 30, 2015. |
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| ABSTRACT |
Objectives:
This study investigated the effects of Paljeong-san on chronic nonbacterial prostatitis induced in rats by estradiol.
Methods:
Rats were divided into three groups. The normal group included rats with no intervention after sham castration. The control group included rats with prostatitis induced by 17β-estradiol after orchiectomy; these rats were orally administered normal saline. The sample group rats were administered Paljeong-san after prostatitis induction. Evaluations included changes in epithelial score, body weight, and prostate weight and volume, as well as histopathological changes in prostate tissue and gene expression of TNF-α, COX-2, and CD68.
Results:
Paljeong-san inhibited histopathological changes and monocyte/macrophage infiltration of the prostate. The epithelial score was higher for the sample group than for the control group (P<0.05). Paljeong-san administration decreased the gene expression of TNF-α and CD68.
Conclusions:
Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression. |
| Key words:
Paljeong-san, prostatitis, inflammation, estradiol |
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