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The Journal of Internal Korean Medicine > Volume 36(1); 2015 > Article
The Journal of Internal Korean Medicine 2015;36(1): 69-75.
A Drug-Induced Liver Injury by Western Medication
Chang-gue Son
Liver and Immunology Research Center, Oriental Medical College in Dae-Jeon University
Correspondence  Chang-gue Son ,Tel: +82-42-229-6807, Fax: +82-42-257-6398, Email: ckson@dju.ac.kr
Received: February 16, 2015,   Accepted: March 19, 2015,   Published online: March 30, 2015.
ABSTRACT
Objectives:
To investigate the clinical features of drug-induced liver injury (DILI) and traditional Korean medicine (TKM) -based management.

Methods:
A female patient diagnosed with DILI caused by Western drugs had been treated with Oriental therapies, then the subjective clinical outcome and biochemical parameters were monitored.

Results:
A 73-year-old female had taken Western drugs (nonsteroidal anti-inflammatory and skeletal muscle relaxants) for about 3 months, and complained of severe abdominal discomfort and tiredness. Her RUCAM score was 9, which met the criteria for DILI (AST 90 IU/L, ALT 100 IU/L, ALP 191 IU/L, and GGT 614 IU/L). She was treated with herbal drugs, moxibustion, and acupuncture, and her symptoms completely resolved, with normalized hepatic enzymes within two weeks.

Conclusions:
This case report provides a clinical characteristic for a typical DILI caused by Western medicine, and shows an example of a TKM-based application.
Key words: drug-induced liver injury, traditional Korean medicine, herbal medicine, RUCAM score
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