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The Journal of Internal Korean Medicine 2014;35(4): 428-438. |
| 木香이 고지방 식이에 의한 비만으로 유발된 인슐린 저항성 mouse의 염증 및 인슐린 저항성에 미치는 영향 |
| 오재선, 마영훈, 최승범, 김종호, 김경국, 전상윤 |
| 동신대학교 한의과대학 내과학교실 |
| Effects of Inula helenium on Inflammation and Insulin Resistance in Obesity-induced
Insulin Resistance Mouse by High Fat Diet |
| Jae-seon Oh, Young-hun Ma, Seung-bum Choi, Jong-ho Kim, Kyung-kook Kim, Sang-yun Jeon |
| Dept. of Internal medicine, College of Korean Medicine, Dong-Shin University |
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Published online: December 30, 2014. |
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| ABSTRACT |
Objectives:
Obesity is an important cause of insulin resistance that leads to obese type 2 diabetes. Recently it has been found that obesity is associated with adipose tissue accumulation which causes systemic inflammation. In this study, we investigated effects of Inula helenium on the inflammation in high fat diet-induced insulin resistance mouse.
Methods:
Insulin resistance was induced in C57BL/6 male mice (19~21 g) on a 60% fat diet. Mice were divided into 3 groups (n=6) of normal, control and Inula helenium. After 12 weeks, body weight, FBS, oral glucose tolerance test (OGTT), serum level of insulin, epididymal fat pad, liver weight and the gene expression of tumor necrosis factor (TNF)-α, interleukin (IL)-6, interleukin (IL)-10 and cluster of differentiation (CD) 68 were measured. Also, adipose tissue macrophage was analyzed by fluorescence activated cell sorting.
Results:
Inula helenium significantly reduces oral glucose tolerance levels, insulin serum level and adipose tissue macrophage. Also Inula helenium increased IL-10 gene expression and decreased CD68 gene expression.
Conclusions:
These results show that Inula helenium has anti-insulin resistance and anti-inflammatory effects on a high fat diet-induced insulin resistance mouse model. |
| Key words:
Inula helenium, obesity, insulin resistance, type 2 diabetes, adipose tissue inflammation |
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