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The Journal of Internal Korean Medicine > Volume 35(3); 2014 > Article
The Journal of Internal Korean Medicine 2014;35(3): 244-261.
製何首烏加味方이 고지혈증 및 산화적 손상에 미치는 영향
윤현덕, 조현경, 유호룡, 설인찬, 김윤식
대전대학교 한의과대학 심계내과학교실
The Effects of Jehasuogamibang on Antioxidation Activity and Dietary Hyperlipidemia-induced Mice
Hyeon-deok Youn, Hyun-kyung Jo, Ho-ryong Yoo, In-chan Seol, Yoon-sik Kim
Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University
Correspondence  Yoon-sik Kim ,Tel: 053-759-8875, Email: manchonhani@naver.com
  Published online: September 30, 2014.
ABSTRACT
Objectives:
This experiments were performed to determine the effects of the Jehasuogamibang (製何首烏加味方: JHGB) on antioxidationactivity and hyperlipidemia induced by a hypercholesterolemic diet in mice.

Methods:
After treatment with JHGB expert safety in cytotoxicity and toxicity of Human fibroblast cells and liver and kidney, effect on Reactive Oxygen Species, serum total cholesterol, LDL-cholesterol, triglyceride, glucose, HDL-cholesterol, lipid peroxid of liver tissue, significantly increased SOD and catalase.

Results:
1. JHGB showed safety in cytotoxicity and toxicity of human fibroblast cells and liver and kidney. 2. JHGB showed significant inhibitory effect on reactive oxygen species. 3. JHGB significantly decreased serum total cholesterol, LDL-cholesterol, triglyceride, and glucose, and significantly increased serum HDL-cholesterol. 4. JHGB significantly decreased lipid peroxide of liver tissue and significantly increased SOD and catalase.

Conclusions:
These results suggest that Jehasuogamibang is effective in antioxidationactivity and dietary hyperlipidemia-induced mice.
Key words: Hyperlipidemia, Antioxidation Activity, Jehasuogamibang
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