| Home | E-Submission | Sitemap | Editorial Office |  
The Journal of Internal Korean Medicine > Volume 35(2); 2014 > Article
The Journal of Internal Korean Medicine 2014;35(2): 175-183.
비알코올성 지방간 세포 모델에서 곤포의 효능과 기전 연구
김소연1,2, 권정남1,2, 이인1,2, 홍진우1,2, 최준용1,2, 박성하1,2, 권민정1, 주명수1, 한창우1,2
1부산대학교 한의학전문대학원
2부산대학교한방병원 한방내과
Research on Anti-lipogenic Effect and Underlying Mechanism of Laminaria japonica on Experimental Cellular Model of Non-alcoholic Fatty Liver Disease
So-yeon Kim1,2, Jung-nam Kwon1,2, In Lee1,2, Jin-woo Hong1,2, Jun-yong Choi1,2, Seong-ha Park1,2, Min-jung Kwun1, Myung-soo Joo1, Chang-woo Han1,2
1School of Korean Medicine, Pu-san National University
2Dept. of Internal Medicine, Korean Medicine Hospital, Pu-san National University
Correspondence  Chang-woo Han ,Tel: 055-360-5957, Fax: 051-510-8420, Email: hancw320@pusan.ac.kr
  Published online: June 30, 2014.
We tried to uncover the anti-lipogenic effect and underlying mechanism of Laminaria japonica on an experimental cellular model of non-alcoholic fatty liver disease.

Methods :
Ethanol extract of Laminaria japonica (LJ) was prepared. Intracellular lipid content of palmitate-treated HepG2 cells was evaluated with or without LJ treatment. We measured the effects of LJ on liver X receptor α (LXRα) and sterol regulatory element-binding transcription factor-1c (SREBP-1c) expression, transcription level of lipogenic genes, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD-1), and nuclear factor erythroid 2-related factor 2 (Nrf2) activation in HepG2 cells.

LJ markedly attenuated palmitate-induced intracellular lipid accumulation in HepG2 cells. LJ suppressed LXRα -dependent SREBP-1c activation, and SREBP-1c mediated induction of ACC, FAS, and SCD-1. Furthermore, LJ activated Nrf2, which plays an important cytoprotective role in non-alcoholic fatty liver disease.

Our study suggests that LJ has the potential to alleviate hepatic lipid accumulation, and this effect was mediated by inhibiting the LXRα-SREBP-1c pathway that leads to hepatic steatosis. In addition, the anti-lipogenic potential may, at least in part, be associated with activation of Nrf2.
Key words: Laminaria japonica, non-alcoholic fatty liver disease, LXRα, SREBP-1c, Nrf2
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Related article
Effects of Ethanol Extract of Benincasa Seeds on the Experimental Cellular Model of Nonalcoholic Fatty Liver Disease  2012 December;33(4)
Editorial Office
Dongguk University Ilsan Oriental Hospital
27, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326 Korea
TEL: +82-31-961-9046   FAX: +82-31-961-9049   E-mail: jikm.edit@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Society of Internal Korean Medicine. All rights reserved.                 Developed in M2Community      |      Admin Login