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The Journal of Internal Korean Medicine > Volume 34(3); 2013 > Article
The Journal of Internal Korean Medicine 2013;34(3): 289-297.
오령산의 고혈압 치료 효과에 대한 체계적 고찰 : 임상 논문을 중심으로
이혜윤1, 강기완1, 이은1, 이승호2, 한창호4, 장인수3
1우석대학교 한의과대학 한의학과
2우석대학교 한의과대학 본초학교실
3우석대학교 한의과대학 한방내과학교실
4동국대학교 한의과대학 한방내과학교실
A Systematic Review on Antihypertensive Effects of Oryeong-san
Hye-yoon Lee1, Ki-wan Kang1, Eun Lee1, Seung-ho Lee2, Chang-ho Han4, In-soo Jang3
1Dept. of Korean Medicine, College of Korean Medicine, Woo-Suk University
2Dept. of Herbology, College of Korean Medicine, Woo-Suk University
3Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University
4Dept. of Internal Medicine, College of Korean Medicine, Dong-Guk University
Correspondence  In-soo Jang ,Tel: 063-220-8608, Fax: 063-220-8616, Email: mackayj@naver.com
  Published online: September 30, 2013.
The purpose of this study was to review the clinical studies on antihypertensive effects of Oryeong-san.

Methods :
We searched papers using KTKP, Oasis, CNKI, PubMed, Embase, Science Direct, CINAHL, J STAGE and CiNii, and the key words “Oryeong-san (韓)”, “Wuling-san (中)”, “Gorei-san (日)”, and “Hypertension” were used. Search range included randomized controlled trials (RCTs), clinical reports, reviews and animal experiments. Papers not matched with inclusion criteria were excluded.

A total 479 studies were found, with 457 excluded during title and abstract screening. After scanning 22 papers, a final 3 RCTs and 6 case reports were selected and analyzed. In the 3 RCTs, the number of patients varied between 65 and 156. Patients with hypertension were randomized into groups for treatment group and control group. They were all treated with antihypertensive drugs (Vamlodipine Besylate, Benazepril, Perindopril); the treatment group was also given modified Oryeong-san. After treatment, results were that blood pressure was significantly decreased in the treatment group, compared to the control. The other 6 case reports reported that modified Oryeong-san alone or the combination of Oryeong-san plus antihypertensive drugs had beneficial effects on blood pressure.

Oryeong-san appears to be effective in improving blood pressure and hypertension-related symptoms. The results of this study could be applied to clinical treatment of hypertension. Further large-scale clinical researches should be conducted.
Key words: Oryeong-san, Wuling-san, Gorei-san, hypertension, blood pressure
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