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The Journal of Internal Korean Medicine > Volume 34(2); 2013 > Article
The Journal of Internal Korean Medicine 2013;34(2): 155-164.
ICR 마우스를 이용한 자음강화탕 및 자음강화탕 발효물의 단회투여 독성시험
이지혜, 곽동훈, 황윤환, 박화용, 마진열
한국한의학연구원
Single Oral Dose Toxicity Study of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Fermented Jaeumganghwa-tang (Ziyinjianghuo-tang) in ICR Mice
Ji-hye Lee, Dong-hoon Kwak, Yoon-hwan Hwang, Hwa-yong Park, Jin-yeul Ma
Korea Institute of Oriental Medicine
Correspondence  Jin-yeul Ma ,Tel: 042-868-9466, Fax: 042-868-9573, Email: jyma@kiom.re.kr
  Published online: June 30, 2013.
ABSTRACT
Objectives:
This study aimed to evaluate the single oral dose toxicity of Jaeumganghwa-tang (Ziyinjianghuo-tang) and Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus in male and female ICR mice.

Methods :
In this single oral toxicity study, non-fermented and fermented Jaeumganghwa-tang (Ziyinjianghuo-tang) were administered to male and female ICR mice as an oral dose of 500, 1000 and 2000 mg/kg. After single administration, body weight changes, general behavior, adverse effects and mortality were determined for 14 days. Serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment.

Results:
There were no mortality or signs of toxicity for 14 days. There were also no significant differences in body weights, organ weights, or serum chemistry values between treatment and control groups.

Conclusions:
These results indicate that the 50% lethal dose of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acipophullus may be over 2000 mg/kg. This finding can be expected to provide scientific evidence for the safety of Jaeumganghwa-tang (Ziyinjianghuo-tang) fermented with Lactobacillus acidophyllus.
Key words: Jaeumganghwa-tang (Ziyinjianghuo-tang), fermentation, acute toxicity, safety, LD50
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