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The Journal of Internal Korean Medicine 2012;33(4): 511-519. |
| 神仙不醉丹 加減方의 숙취 예방효과에 대한 이중맹검 무작위배정 교차임상 예비연구 |
| 정현숙1,2, 강세영1, 한현진1, 장인수1 |
1우석대학교 한의과대학 한방내과학교실
2효사랑병원 |
| The Effects of SBD-1 on Hangover Syndrome :
a Randomized Double-blind Crossover Preliminary Study |
| Hyun-suk Jeong1,2, Sei-young Kang1, Hyun-jin Han1, In-soo Jang1 |
1Dept. of Internal Medicine, College of Korean Medicine, Woo-Suk University
2Hyosarang Family Hospital |
| Correspondence |
In-soo Jang ,Tel: 063-220-8615, Fax: 063-227-6234, Email: makayj@hanmail.net
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Published online: December 30, 2012. |
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| ABSTRACT |
Objectives:
This study investigated the effect of Sinseonbulchuidan (SBD-1) on hangover syndrome. We undertook this study to test whether SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover.
Methods :
Fifteen healthy volunteers participated in this double-blind randomized crossover study. All participants received either SBD-1 or indistinguishable placebo capsules before alcohol consumption. The primary outcome measure was the difference in hangover severity scores between SBD-1 and placebo intervention. Secondary outcome measure was the difference in profile of mood states (POMS) between SBD-1 and placebo intervention.
Results:
After alcohol exposure, the overall symptom scores were significantly decreased in the SBD-1 group compared with those given a placebo. The mean scores for the hangover symptoms were high in the placebo group, and statistical significance was observed in 4 symptom scores (loss of appetite, stomachache, nausea, and total score). There were no differences in the POMS and cognitive performance test results between SBD-1 and placebo intervention.
Conclusions:
We conclude that the SBD-1 is effective in preventing the signs and symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings. |
| Key words:
Sinseonbulchuidan, alcohol hangover, Korean medicine, acute hangover scale |
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