| 무증상성 열공성 뇌경색 환자에서 호모시스테인과 대사증후군의 상관관계에 대한 연구 |
| 신윤리, 이재욱, 이승연, 윤용재, 정현윤, 김경민, 김영균 |
| 동의대학교 한의과대학 내과학교실 |
| Correlation between Metabolic Syndrome and Plasma Homocysteine Level
in Patients with Silent Lacunar Infarction |
| Yoon-ri Shin, Jae-wook Lee, Seung-yeon Lee, Yong-jae Yun, Hyun-yun Jeong, Kyoung-min Kim, Young-kyun Kim |
| Dept. of Internal Medicine, College of Oriental Medicine, Dong-Eui University |
| Correspondence |
Young-kyun Kim ,Tel: 051-850-8620, Fax: 051-867-5162, Email: ygkim@deu.ac.kr
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Published online: September 30, 2012. |
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| ABSTRACT |
Objectives:
This clinical study was done to examine metabolic syndrome (MS) and plasma homocysteine (HCY) level in patients with silent lacunar infarction (SLI) and in normal controls.
Methods :
A total of 154 patients, who were over 20 years of age and visited the stroke prevention check-up center of a university hospital from December 2006 to December 2010, were examined by brain CT or brain MRI, and classified into two groups. We compared the components of MS and HCY levels between patients with SLI (n=74) and normal controls (n=80). Modified ATP Ⅲ definition was used for diagnosis of MS while Korean standard for waist circumference was used.
Results:
Prevalence of MS was significantly higher in the SLI group than the normal group. HCY was also significantly higher in the SLI group than the noraml, and the odds ratio (OR) for SLI, comparing high HCY level (≥10 μmol/L) with low HCY level (<10 μmol/L), was 3.64 (95% confidence interval (CI); 1.81-7.29, p<.0001). However, there was no correlation between MS and HCY in the SLI group. Prevalence of diabetes and hypertension (HT) was higher in the SLI group than the normal group, but there was no significant difference in blood lipids level between the SLI and normal groups. Of note, HT itself was enough to be an independent risk factor for SLI (OR; 4.58, 95% CI; 1.91-11.01, p=0.001). Body mass index, waist circumference, waist-hip ratio and visceral fat area were significantly higher in the SLI than normal group, and visceral fat area was enough to be an independent risk factor for SLI (OR; 2.41, 95% CI; 1.04-5.59, p=0.040).
Conclusions:
SLI is shown to have significant correlation with HCY and prevalence of MS, however there is no relationship between HCY and prevalence of MS in patients with SLI. |
| Key words:
silent lacunar infarction, metabolic syndrome, homocysteine |
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