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The Journal of Internal Korean Medicine > Volume 29(4); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(4): 1100-1114.
生地黃이 신절제술로 유도된 만성신부전 Rat에 미치는 影響
최종배, 김용성, 한양희
동신대학교 한의과대학 신계내과학교실
The Effects of Rehmannia on Nephrectomy-induced Chronic Renal Failure Rats
Jong-bae Choe, Young-seong Kim, Yang-hee Han
Dept. of Internal Medicine. College of Oriental Medicine, Dongshin University
Correspondence  Young-seong Kim ,Tel: 061-280-7921, Fax: 061-280-7788, Email: underlo@hanmail.net
  Published online: December 30, 2008.
ABSTRACT
The aim of the study was to investigate recovery effects of Rehmannia, which has been used clinically for chronic renal failure therapy. Mice had 5/6 nephrectomy to induce chronic renal failure. The results were as follows: 1. The protein amount in urine per 24hrs of the Rehmannia-treated group was significantly reduced compared to the control. 2. The albumin amount in the blood of the Rehmannia-treated group significantly increased compared to the control. The creatinine, total-cholesterol, LDL-cholesterol and triglyceride levels in serum of the Rehmannia-treated group as compared to the control were significantly inhibited. 3. The structural change in kidney of the Rehmannia-treated group was significantly inhibited compared to the control. 4. The factor (macrophage/monocyte antigen (ED-1), type IV collagen and angiotensin II type 1 (AT1) receptor) of the Rehmannia-treated group was significantly inhibited compared to the control, which induced the structural change in kidneys. The above results suggest that Rehmannia partially improved kidney function.
Key words: Rehmannia, Nephrectomy, Chronic renal failure
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