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The Journal of Internal Korean Medicine > Volume 29(4); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(4): 1011-1024.
급성기 중풍환자의 발병시간에 따른 특성 및 위험인자 연구
김미영1, 김영지1, 이승엽1, 최원우1, 임정태1, 김창현1, 민인규1, 박성욱2, 정우상1, 문상관1, 박정미2, 고창남2, 조기호1, 김영석1, 배형섭2
1경희대학교 한의과대학 심계내과
2경희대학교 동서신의학병원 중풍 뇌질환센터
The General Characteristics and Risk Factors Study According to Onset Time in Acute Stroke Patients
Mi-young Kim1, Young-jee Kim1, Seung-yeop Lee1, Won-woo Choi1, Jung-tae Leem1, Chang-hyun Kim1, In-kyu Min1, Sung-wook Park2, Woo-sang Jung1, Sang-kwan Moon1, Jung-mi Park2, Chang-nam Ko2, Ki-ho Cho1, Young-suk Kim1, Hyung-sup Bae2
1Department of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University, Seoul, Korea
2Stroke & Neurological disorders center, East-West Neo Medical Center, College of Oriental Medicine, Kyung-Hee University, Seoul, Korea
Correspondence  Sang-kwan Moon ,Tel: 02-958-9275, Fax: 02-958-9132, Email: total1222@hanmail.net
  Published online: December 30, 2008.
ABSTRACT
Objectives:
The aim of this study was to assess the distribution of general characteristics and risk factors according to onset time in acute stroke patients.

Methods :
We studied hospitalized patients within 4 wks after the onset of stroke who were admitted to the Department of Internal Medicine at Kyunghee University Oriental Medical Hospital, Kyunghee University East-West Neo Medical Hospital, Kyungwon University Songpa Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, and Dongguk University Ilsan Oriental Medical Hospital from April 2007 to August 2008. The 24-hour day was divided into quartiles (6:00 to 12:00, 12:00 to 18:00, 18:00 to 24:00 and 24:00 to 6:00). We analyzed the general characteristics and risk factors according to onset time in acute stroke patients.

Results:
468 subjects were included into the final analysis. 1. The most common time period for ischemic stroke onset was between 6:00 and 12:00. It demonstrated a 50% excess risk between 6:00 and 12:00. 2. On the demographic variables of the patients, the rate of hypertension was significantly higher from 18:00 to 24:00 than 24:00 to 6:00. 3. There was no significant difference of stroke type, Sasang constitution, or lifestyle between times. 4. According to the blood test, high density lipoprotein cholesterol was significantly higher at 24:00 to 6:00 and lower at 12:00 to 18:00 than other time-groups. 5. The patients diagnosed with metabolic syndrome were significantly more at 12:00 to 18:00 and fewer at 24:00 to 6:00. 6. Hypertension and coffee drinking showed close relationship with patients whose stroke occurred while awake in multivariate analysis.

Conclusions:
The above results showed that the overall tendency of acute stage cerebral infarction patients varied according to their onset time. These results can be utilized in the future as a basis material.
Key words: Ischemic stroke, Onset time, Risk factors, HTN, Coffee Drinking
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