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The Journal of Internal Korean Medicine 2008;29(2): 456-468. |
| 加味四君子湯이 OVA로 유발된 천식 마우스에 미치는 영향 |
| 손지우1, 신조영1, 이시형2 |
1원광대학교 한의과대학 폐계내과학교실
2원광대학교 한의학전문대학원 |
| Effects of Gamisagunja-tang in an Ovalbumin(OVA)-Induced Allergic Asthma in Mice |
| Ji-woo Son1, Jo-young Shin1, Si-hyeong Lee2 |
1Department of Internal Medicine, College of Oriental Medicine Wonkwang University
2Department of Professional Graduate School of Oriental Medicine Wonkwang University |
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Published online: June 30, 2008. |
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| ABSTRACT |
Objective :
The purpose of this study was to investigate the effects of Gamisagunja-tang(GS) on the airway hyper-reactivity (AHR), cytokine production and T cell activation during the ovalbumin (OVA)-induced allergic asthma in mice.
Materials and Methods :
BALB/c mice were sensitized and challenged with 100 mg of OVA and 1 mg of aluminum potassium sulfate intraperitoneally on days 1 and 7. On day 14, mice were challenged on 3 consecutive days with 5% OVA. AHR and bronchoalveolar fluid (BALF), total inflammatory cell count and the production of cytokines were measured.
Results:
GS significantly suppressed the infiltration of inflammatory cells in the lung tissue and AHR. GS significantly down regulated the production of IL-4, IL-5 and increases of INF-γ in BALF. GS reduced the population of eosinophils from lung and spleen in OVA-induced allergic asthma. GS reduced the population of CD4+ CD69+ CD25- T cells in OVA-induced allergic asthma
Conclusion:
These results suggest that GS may inhibit the production of IL-4, IL-5 and infiltration of eosinophils and be beneficial oriental medicine for allergic asthma. |
| Key words:
Gamisagunja-tang, asthma, cytokines, T cell. |
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