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The Journal of Internal Korean Medicine > Volume 29(2); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(2): 432-442.
雙降湯이 高cholesterol 食餌로 誘發된 高脂血症 白鼠에 미치는 影響
이재휘, 임승민, 안정조, 조현경, 김윤식, 설인찬, 유호룡
대전대학교부속한방병원 심계내과학교실
The Effects of Ssanggang-tang(Ssanggang-tang) on Rat with Induced Hyperlipidemia
Jae-hwi Lee, Seung-min Lim, Joung-jo An, Hyun-kyung Jo, Yoon-sik Kim, In-chan Seol, Ho-rhyong Yoo
Department of Internal Medicine, College of Oriental Medicine, Daejeon University
Correspondence  Ho-rhyong Yoo ,Tel: 042-470-9131, Fax: 042-470-9007, Email: medicdragon@hanmail.net
  Published online: June 30, 2008.
Objective :
Ssanggang-tang(SGT) is noted as an effective method to treat hyperlipidemia in China. The main purpose of this study was analysis of the effects of Ssanggang-tang(SGT) on rats induced with caused hyperlipidemia.

Methods :
We observed 3 experimental groups: normal, control, and SGT. Rats were provided a normal diet in the normal group, and the other groups were provided a hyperlipidemic diet to induce hyperlipidemia. After 2 weeks, SGT was treated in the SGT group. For 6 weeks, values related to hyperlipidemia were observed in the 3 experimental groups.

SGT decreased some values related to hyperlipidemia like total cholesterol, low density lipoprotein cholesterol(LDL cholesterol), triglyceride, acetocoenzyme A acetyltransferase(ACAT), and 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase). However, it showed no effect on weight change or high density lipoprotein cholesterol(HDL cholesterol).

These results suggest that SGT might be effective in treatment and prevention of hyperlipidemia.
Key words: Ssanggang-tang, Hyperlipidemia, Cholesterol.
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