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The Journal of Internal Korean Medicine > Volume 29(2); 2008 > Article
The Journal of Internal Korean Medicine 2008;29(2): 432-442.
雙降湯이 高cholesterol 食餌로 誘發된 高脂血症 白鼠에 미치는 影響
이재휘, 임승민, 안정조, 조현경, 김윤식, 설인찬, 유호룡
대전대학교부속한방병원 심계내과학교실
The Effects of Ssanggang-tang(Ssanggang-tang) on Rat with Induced Hyperlipidemia
Jae-hwi Lee, Seung-min Lim, Joung-jo An, Hyun-kyung Jo, Yoon-sik Kim, In-chan Seol, Ho-rhyong Yoo
Department of Internal Medicine, College of Oriental Medicine, Daejeon University
Correspondence  Ho-rhyong Yoo ,Tel: 042-470-9131, Fax: 042-470-9007, Email: medicdragon@hanmail.net
  Published online: June 30, 2008.
ABSTRACT
Objective :
Ssanggang-tang(SGT) is noted as an effective method to treat hyperlipidemia in China. The main purpose of this study was analysis of the effects of Ssanggang-tang(SGT) on rats induced with caused hyperlipidemia.

Methods :
We observed 3 experimental groups: normal, control, and SGT. Rats were provided a normal diet in the normal group, and the other groups were provided a hyperlipidemic diet to induce hyperlipidemia. After 2 weeks, SGT was treated in the SGT group. For 6 weeks, values related to hyperlipidemia were observed in the 3 experimental groups.

Results:
SGT decreased some values related to hyperlipidemia like total cholesterol, low density lipoprotein cholesterol(LDL cholesterol), triglyceride, acetocoenzyme A acetyltransferase(ACAT), and 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMG-CoA reductase). However, it showed no effect on weight change or high density lipoprotein cholesterol(HDL cholesterol).

Conclusion:
These results suggest that SGT might be effective in treatment and prevention of hyperlipidemia.
Key words: Ssanggang-tang, Hyperlipidemia, Cholesterol.
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