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The Journal of Internal Korean Medicine 2008;29(1): 117-129. |
| 內消散의 정상 및 위 유문부 확장 흰 쥐의 위 운동성에 대한 효능 |
| 김진석, 윤상협 |
| 경희대학교 한의과대학 비계내과학교실 |
| Effect of Naeso-san on Gastric Motility between Normal Intact and Antral Dilatated Rats |
| Jin-seok Kim, Sang-hyub Yoon |
| 3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University |
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Published online: March 30, 2008. |
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| ABSTRACT |
Background & Objective :
Naeso-san(NSS) has been used for the treatment of functional dyspepsia, regarded as a
gastric dysmotility disease. A main cause of gastric dysmotility is antral dilatation or antroduodenal uncoordination. Therefore,
we investigated the effect of NSS on gastric motility and its mechanism of action, as well as the morphologic changes in antral
dilatated rats.
Methods :
Antral dilatated rats were induced by wrapping a nonabsorbable rubber ring(D:6mm, W:4mm, T:1mm)
around the 1st portion of the duodenum for 8 weeks. Then morphologic changes were investigated and compared with normal
intact rats before and after 8 weeks.
Gastric emptying was measured by administration of normal saline(NS) or NSS in normal intact and antral dilatated rats.
In another series of experiments to evaluate the mechanism of NSS under delayed conditions, normal intact rats were treated
with atropine sulfate(1㎎/㎏, s.c.), quinpirole HCl(0.3mg/kg, i.p.), NAME(NG-nitro-L-arginine methyl ester, 75㎎/㎏, s.c.) and
cisplatin(10㎎/㎏, i.p.), respectively.
The myoelectrical activity of the gastric smooth muscle was recorded in normal intact and antral dilatated rats. The
contractile waves were measured for 30 minutes before and after administration of each solution(NS, NSS).
Results:
Body weight gain of antral dilatated rats was significantly lower than that of the controls. Futhermore, we found
the thickness of the mucosal and muscular layers and surface area of the stomach increased significantly compared with
controls.
NSS 278㎎/㎏ improved gastric emptying more than normal saline or NSS 93㎎/㎏ in normal intact(p=0.026) and antral
dilatated rats(p=0.03). NSS enhanced gastric emptying significantly in the NAME treated group(p=0.002).
NSS 278㎎/㎏ increased the significant postprandial dominant power than that of NS in normal intact rats, whereas there
was no statistical significance in antral dilatated rats.
Conclusions:
NSS stimulates gastric motility through the cholinergic pathway. We expect that pathologic model with
antral dilatation can be used as an exprimental tool which is similar to dyspepsia and NSS would be effective especially in
dysmotility-like functional dyspepsia with antral dilatation or impaired reservoir functions such as gastric adaptive relaxation. |
| Key words:
Naeso-san, antral dilatation, gastric emptying, gastric myoelectrical activity, rat |
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