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The Journal of Internal Korean Medicine > Volume 28(4); 2007 > Article
The Journal of Internal Korean Medicine 2007;28(4): 902-910.
제 2형 당뇨병 및 당뇨 합병증의 발생과 Peroxisome Proliferator-Activated Receptor-γ2 C161T 유전자 다형성과의 관계
이병철, 안세영, 두호경, 안영민
경희대학교 한의과대학 신계내과학교실
The Association between Peroxisome Proliferator-Activated Receptor-Gamma C161T Polymorphism and Type 2 Diabetic Complications.
Byung-cheol Lee, Se-young Ahn, Ho-kyung Doo, Young-min Ahn
Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University
Correspondence  Young-min Ahn ,Tel: 02-958-9097, Fax: 02-958-9158, Email: omdan@hanmail.net
  Published online: December 30, 2007.
ABSTRACT
Objective :
Peroxisome proliferator-activated receptor (PPAR)-gamma, a transcription factor in adipocyte differentiation, has important effects on insulin sensitivity, atherosclerosis, endothelial cell function and inflammation. Through these effects, PPAR-gamma2 might be involved with type 2 diabetes and vascular disease, including diabetic complications. Recently, it has been reported that the C161T polymorphism in the exon 6 of PPAR-gamma is associated with type 2 diabetes interacting with uncoupling protein 2 (UCP2) gene, and is associated with acute myocardial infarction. We studied the association of this polymorphism with type 2 diabetes and its complications, such as retinopathy, ischemic stroke, nephropathy and neuropathy in Korean non-diabetic and type 2 diabetic populations.

Methods :
Three hundred and thirty eight type 2 diabetic patients (retinopathy: 64, ischemic stroke: 67, nephropathy: 39 and neuropathy: 76) and 152 healthy matched control subjects were evaluated. The PPAR-gamma C161T polymorphism was analyzed by PCR-RFLP.

Results:
PPAR-gamma C161T genotype and allele frequency did not show significant differences between type 2 diabetic patients and healthy controls (T allele: 17.0 vs. 14.5, OR= 1.21, P=0.3188). In the analysis for diabetic complications, T allele in diabetic nephropathy was significantly higher than controls (P=0.0358). T allele in the ischemic stroke patients was also higher than healthy controls, although it had no significance (P=0.1375).

Conclusions:
These results suggest that the C161T polymorphism of the PPAR-gamma gene might be associated with diabetic nephropathy in type 2 diabetes.
Key words: type 2 diabetes mellitus, diabetic complication, peroxisome proliferator-activated receptor-γ2, polymorphism
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